56116-35-9

Upstream product

• 128399-50-8 3-chloromethyl-2-methylpentane 
• 41178-79-4 2-methyl-3-hydroxymethyl-pentene-⁽³⁾ 
• 32444-33-0 methyl 2-ethyl-3-methylbutyrate 
• 503-74-2 3-methylbutyric acid 
• 53603-94-4 stigmasterol methyl ether 
• 24910-63-2 2,3-dimethyl-pent-2-ene 
• 1522-46-9 ethyl 2-isopropylacetoacetate 
• 63791-85-5 2-Ethyl-3-methylbutansaeure-ethylester 
• 56006-49-6 2-ethyl-3-methyl-butyric acid 
• 109929-22-8 1,2,3-(CH₃)3C₃H₂Br 
• 2747-53-7 3-methyl-3-penten-2-ol 

Downstream Products

• 55504-75-1 (2-Ethyl-3-methyl-butoxysulfonyl)-phenyl-acetic acid 
• 56006-50-9 toluene-4-sulfonic acid-((S)-2-ethyl-3-methyl-butyl ester) 
• 1026272-78-5 (1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((1R,4R)-4-ethyl-1,5-dimethyl-hexyl)-7a-methyl-octahydro-indene 
• 76740-15-3 (S)-2-ethyl-3-methylbutanal 
• 92372-38-8 2-ethyl-3-methyl-1-(p-tolylsulfonyloxy)butane 
• 170511-91-8 2-ethyl-3-methylbutyl phenyl sulphone 
• 170511-90-7 2-ethyl-3-methylbutyl phenyl sulfide 

Relevant academic research and scientific papers

Syntheses and evaluation of anticonvulsant activity of novel branched alkyl carbamates

A novel class of 19 carbamates was synthesized, and their anticonvulsant activity was comparatively evaluated in the rat maximal electroshock (MES) and subcutaneous metrazol (scMet) seizure tests and pilocarpine-induced status epilepticus (SE) model. In spite of the alkyl-carbamates' close structural features, only compounds 34, 38, and 40 were active at the MES test. The analogues 2-ethyl-3-methyl-butyl-carbamate (34) and 2-ethyl-3-methyl-pentyl- carbamate (38) also exhibited potent activity in the pilocarpine-SE model 30 min postseizure onset. Extending the aliphatic side chains of homologous carbamates from 7 to 8 (34 to 35) and from 8 to 9 carbons in the homologues 38 and 43 decreased the activity in the pilocarpine-SE model from ED50 = 81 mg/kg (34) to 94 mg/kg (35) and from 96 mg/kg (38) to 114 mg/kg (43), respectively. The most potent carbamate, phenyl-ethyl-carbamate (47) (MES ED50 = 16 mg/kg) contains an aromatic moiety in its structure. Compounds 34, 38, 40, and 47 offer the optimal efficacy-safety profile and, consequently, are promising candidates for development as new antiepileptics.

A convenient synthesis of the side-chain of sterols

Potassium t-butoxide-induced Ramberg-Backlund rearrangement of chlorosulfones formed from a cyclopregnane-20-thiomethanol derivative has been shown to give Δ22-unsaturated steroids with high trans stereoselectivity.

SYNTHESIS OF (24R)-HOMOBRASSINOLIDE

The synthesis from stigmasterol of C-29 brassinosteroids containing an (R)-ethyl group at C24 - (24R)-homocastasterone and (24R)-homobrassinolide - is described.The structure of the carbon skeleton of the side-chain was achieved by condensing a C-22 aldeh

SYNTHESIS OF SOME NEW CHOLESTERYL ESTERS OF CHIRAL ALKANOIC ACIDS.

Six new cholesteryl esters have been prepared from chiral alkanoic acids. Oxidation of 2(S)-methylbutanol and 2(S)-ethyl-3-methybutyraldehyde gave the corresponding butyric acids, while condensation of the tosylates of the corresponding alcohols with diethyl malonate led ultimately to the substituted hexanoic acids. 2(R)-Methylpentanoic and ( minus )-2-ethylhexanoic acids were commercially available.