56138-44-4Relevant academic research and scientific papers
Synthesis of 4-methyldienoates using a vinylogous horner-wadsworth-emmons reagent. application to the synthesis of trichostatic acid
Markiewicz, John T.,Schauer, Douglas J.,Loefstedt, Joakim,Corden, Steven J.,Wiest, Olaf,Helquist, Paul
supporting information; experimental part, p. 2061 - 2064 (2010/06/16)
Chemical Equation Presented The utility of the unsaturated phosphonate 1 as a vinylogous Horner-Wadsworth-Emmons reagent was explored in reactions with, aldehydes affording 4-methyldienoate esters. Factors that affect E/Z selectivity were studied. A simplified synthesis of trichostatic acid 3 was accomplished, to demonstrate utility of this reagent.
