56157-92-7 Usage
General Description
4-chloro-2-methylbenzenesulfonyl chloride is a chemical compound that is used in various organic synthesis reactions. It is a sulfonyl chloride derivative and belongs to the class of aryl sulfonyl chlorides. 4-chloro-2-methylbenzenesulfonyl chloride is often utilized as a reagent in the preparation of various pharmaceutical and agrochemical products. It is known for its ability to act as a strong electrophile in aromatic substitution reactions, and it is also used as a building block in the synthesis of various organic compounds. Due to its versatile nature, 4-chloro-2-methylbenzenesulfonyl chloride has found applications in the field of medicinal chemistry and drug discovery, as well as in the production of specialty chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 56157-92-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,1,5 and 7 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 56157-92:
(7*5)+(6*6)+(5*1)+(4*5)+(3*7)+(2*9)+(1*2)=137
137 % 10 = 7
So 56157-92-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H6Cl2O2S/c1-5-4-6(8)2-3-7(5)12(9,10)11/h2-4H,1H3
56157-92-7Relevant articles and documents
Synthesis of 3,4-dihydro-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxides and their evaluation as ligands for NMDA receptor glycine binding site
Bluke, Zanda,Paass, Einars,Sladek, Meik,Abel, Ulrich,Kauss, Valerjans
, p. 664 - 673 (2016/05/09)
A series of 2-substituted 3,4-dihydro-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxides were synthesized and evaluated for their affinity to the glycine binding site of the N-methyl-d-aspartate (NMDA) receptor. The binding affinity was determined by the displacement of radioligand [3H]MDL-105,519 from rat cortical membrane preparations. The most attractive structures in the search for prospective NMDA receptor ligands were identified to be 2-arylcarbonylmethyl substituted 3,4-dihydro-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxides. It has been demonstrated for the first time that the replacement of NH group in the ligand by sp3 CH2 is tolerated. This finding may pave the way for previously unexplored approaches for designing new ligands of the NMDA receptor.
