56159-89-8

Usage

Uses

Used in Pharmaceutical Synthesis:
2',6'-Difluorophenacyl bromide is used as a key reagent in the pharmaceutical industry for the preparation of various organic compounds. Its bromination and acylation reactions facilitate the creation of molecules with specific functional groups and reactivities, which are essential for the development of new drugs and therapeutic agents.
Used in Agrochemical Production:
In the agrochemical sector, 2',6'-Difluorophenacyl bromide serves as an important intermediate for the synthesis of various agrochemicals. Its ability to participate in bromination and acylation reactions allows for the production of molecules with unique properties, enhancing the effectiveness of pesticides, herbicides, and other agricultural chemicals.
Used in Fine Chemicals Synthesis:
2',6'-Difluorophenacyl bromide is also utilized in the synthesis of fine chemicals, which are high-purity chemicals used in various applications such as fragrances, dyes, and specialty chemicals. Its strong brominating and acylating properties enable the production of organic molecules with specific characteristics, contributing to the development of innovative and high-quality fine chemicals.

Upstream product

• 13670-99-0 2,6-difluoroacetophenone 

Downstream Products

• 40017-76-3 3-(2,6-difluorophenyl)-3-oxopropanenitrile 
• 657410-74-7 2-[4-Amino-5-(2,6-difluoro-benzoyl)-thiazol-2-ylamino]-pyridine-5-carboxylic Acid Ethyl Ester 
• 872166-78-4 4-amino-5-(2,6-difluorobenzoyl)-1-(4-methoxybenzyl)-2-(4-phenoxyphenyl)-1H-pyrrole-3-carbonitrile 
• 872166-87-5 4-amino-5-(2,6-difluorobenzoyl)-1-(4-methoxybenzyl)-2-(4-nitrophenyl)-1H-pyrrole-3-carbonitrile 
• 872166-92-2 4-amino-5-(2,6-difluorobenzoyl)-1-(4-methoxybenzyl)-2-(4-methoxyphenyl)-1H-pyrrole-3-carbonitrile 
• 304669-72-5 3-(4-bromophenyl)-6-(2,6-difluorophenyl)-[1,2,4]triazine 
• 486413-80-3 4-[4-amino-5-(2,6-difluoro-benzoyl)-thiazol-2-ylamino]-benzoic acid ethyl ester 
• 746630-43-3 4-[4-amino-5-(2,6-difluoro-benzoyl)-thiazol-2-ylamino]-benzenesulfonyl fluoride 
• 1336804-21-7 C₁₁H₆F₂N₂S 
• 1336804-36-4 C₁₂H₆F₂N₂OS 
• 1336804-56-8 NSC 747413 
• 1429403-13-3 3-(2,6-difluoro-phenyl)-7-(2-ethyl-5-trifluoromethyl-2H-pyrazol-3-yl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine 
• 1429403-22-4 3-(2,6-difluoro-phenyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine 
• 1429403-23-5 7-bromo-3-(2,6-difluoro-phenyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine 

Relevant academic research and scientific papers

High Chemo-/Stereoselectivity for Synthesis of Polysubstituted Monofluorinated Pyrimidyl Enol Ether Derivatives

A novel intramolecular Smiles rearrangement of α-fluoro-β-keto-pyrimidylsulfones (usually used as a carbon nucleophile) was developed, providing a versatile avenue for synthesis of tri/tetra-substituted monofluorinated pyrimidyl enol ethers. Among these, diverse (Z)-monofluorovinylsulfones and sulfinates were efficiently assembled by adding extra electrophile and fine-tuning reaction conditions. The process is triggered by a keto-enol tautomerism from enol oxyanion to pyrimidine 2-carbon, completely different from the classical carbon nucleophilic addition reaction approach.

BENZOXAZINE DERIVATIVES AS CRAC MODULATORS

Compounds of the formula (I): or pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with calcium release-activated calcium channels (CRAC).

Utilization of the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide scaffold in the design of potential inhibitors of human neutrophil proteinase 3

The S′ subsites of human neutrophil proteinase 3 (Pr 3) were probed by constructing diverse libraries of compounds based on the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide using combinational and click chemistry methods. The multiple points of diversity embodied in the heterocyclic scaffold render it well-suited to the exploration of the S′ subsites of Pr 3. Molecular modeling studies suggest that further exploration of the S′ subsites of Pr 3 using the aforementioned heterocyclic scaffold may lead to the identification of highly selective, reversible competitive inhibitors of Pr 3.

Acid secretion inhibitor

The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.

Antiproliferative 2-(heteroaryl)-aminothiazole compounds and pharmaceutical compositions, and methods for their use

Compounds represented by the Formula (I): are described. The compounds and pharmaceutical compositions containing them may be used in inhibiting and/or modulating protein kinases, in treating or preventing diseases associated with protein kinases, and/or in treating or preventing cellular proliferative diseases.

ANTIPROLIFERATIVE 2-(SULFO-PHENYL)-AMINOTHIAZOLE DERIVATIVES

Aminothiazole compounds substituted with sulfur-containing groups are represented by the Formula (I), and their pharmaceutically acceptable salts, prodrugs, active metabolites, and pharmaceutically acceptable salts of said metabolites are described. These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.

N-HETEROCYCLYL-SUBSTITUTED AMINO-THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS

Aminothiazole compounds with N-containing cycloalkyl at the 2-amino position which are represented by the Formula (I), or a pharmaceutically acceptable prodrug of said compound, or pharmaceutically acceptable salt of said compound, modulate and/or inhibit the cell proliferation and activity of protein kinases.

Thiazole benzamide derivatives and pharmaceutical compositions for inhibiting cell proliferation, and methods for their use

Aminothiazole compounds with mono-/di-substituted benzamide are represented by the Formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable prodrugs, pharmaceutically active metabolites, and pharmaceutically acceptable salts of said metabolites are described. These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.

Pesticidal triazine-derivatives

A compound of formula wherein R1 is unsubstituted or substituted aryl or heteroaryl, the substituents of the aryl and heteroaryl rings being selected, for example, from the group consisting of OH, halogen, CN, NO2, C1-C6alkyl, C3-C8cycloalkyl, C1-C6alkyl-C3-C8cycloalkyl, C3-C8cycloalkyl-C1-C6alkyl, C1-C6haloalkyl, C3-C8halocycloalkyl, C1-C6alkoxy and phenyl; phenoxy; phenylthio; phenylamino; and phenyl-(C1-C6alkyl)-amino; the substituents of the phenoxy, phenylthio, phenylamino and phenyl-(C1-C6alkyl)-amino groups being selected from the group consisting of halogen, CN, NO2, C1-C6alkyl, C3-C8cycloalkyl, C1-C6haloalkyl, C3-C8halocycloalkyl, C1-C6alkoxy, C3-C8cycloalkoxy, C1-C6alkylthio, C3-C8cycloalkylthio, C1-C6haloalkylthio and C3-C8halocycloalkylthio; R2 is, for example, H, OH, halogen, CN, NO2, C1-C6alkyl or C1-C6alkoxy; A is, for example, a single bond, C1-C12alkylene, O or O(C1-C12alkylene); R4 is H, C1-C6alkyl, C3-C8cycloalkyl, C1-C6haloalkyl, C1-C6alkoxy, N(R5)2 or C1-C6alkoxy-C2-C6alkyl; R5 is H, C1-C6alkyl, C3-C8cycloalkyl, C1-C6haloalkyl or aryl-C1-C6alkyl; X1 is R10; X2 and X3 are each independently of the other H or R10; R10 is, for example, halogen, CN, NO2, C1-C6alkyl or C3-C8cycloalkyl; and n is 0, 1 or 2, and to their physiologically tolerable and agrochemically acceptable addition compounds, and where appropriate to E/Z isomers, to mixtures of E/Z isomers and/or to tautomers, in each case in free form or in salt form. The compounds, in free form or in agrochemically acceptable salt form, exhibit advantageous pesticidal properties. They are suitable especially in the control of pests in agriculture and stored goods and also in the keeping of domestic animals.