56167-91-0

Upstream product

• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 56167-90-9 α-(2-aminomethyl-1,4-cyclohexadienyl)acetic acid 

Downstream Products

• 56167-92-1 [2-(N-t-Butoxycarbonylaminomethyl)-1-cyclohexen-1-yl]-acetic acid 

Relevant academic research and scientific papers

Δ2,3 -0-2-Isocephem-4-carboxylic acid and derivatives as antibacterial agents

There is described the stereoselective total synthesis of novel Δ2,3 -1,4-morpholine-2-carboxylic acids possessing a fused β-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system r

Δ2,3-0-2-Isocephem-4-carboxylic acid and derivatives thereof as antibacterial agents

There is described the stereoselective total synthesis of novel Δ2,3 -1,4-morpholine-2-carboxylic acids possessing a fused β-lactam ring in the 1, 6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system

Δ2,3 -1,4-MORPHOLINE-2-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF USEFUL IN PREPARATION OF ANTIBACTERIA AGENTS

There is described novel substituted Δ2,3 -1, 4-morpholine-2-carboxylic acids possessing a fused β-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula STR1 wherein Q is hydrogen or alkyl and X is amino. Also included in the invention are compounds of the above formula in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. The compounds and their physiologically hydrolyzed esters and pharmaceutically acceptable salts are useful as intermediates in the preparation of antibacterial agents.

7-[α-(2-Aminomethyl-1-cyclohexenyl)-acetamido]-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids

7-[α-(2-Aminomethyl-1-cyclohexyl)-acetamido]-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids, and their nontoxic, pharmaceutically acceptable salts and their Schiff bases, as made by reaction of salicylaldehyde with the free amino group, are valuable as antibacterial agents and are particularly valuable as therapeutic agents in poultry and animals, including man, in the treatment of infectious diseases caused by many Gram-positive and Gram-negative bacteria.