5617-92-5Relevant articles and documents
Dauben,W.G.,Shaffer,G.W.
, p. 2301 - 2306 (1969)
A diastereoselective synthesis of (1SR,3SR,7RS)-3-methyl-α- himachalene, the sex pheromone of the sandfly, Lutzomyia longipalpis (Diptera: Psychodidae)
Dufour, Samuel,Castets, Pascalie,Pickett, John A.,Hooper, Antony M.
, p. 5102 - 5108 (2012)
The sandfly, Lutzomyia longipalpis, vectors the causative agent of visceral leishmaniasis in the New World. The male-produced pheromone, (1S,3S,7R)-3-methyl-α-himachalene provides an opportunity for pest managing this pest problem by influencing the behaviour of the biting female. Previous syntheses of the pheromone have all focused on a late stage Diels-Alder cyclisation to generate the bicyclic cis-himachalene skeleton. By adopting a new retrosynthetic analysis that depends on an early stage Diels-Alder cyclisation, the number of steps has been reduced to ten, of which five are catalytic and so provides access to quantities suitable for field-scale experiments.
Diaminodiphosphine tetradentate ligand and ruthenium complex thereof, and preparation methods and applications of ligand and complex
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Paragraph 0316-0319, (2019/11/04)
The invention discloses a diaminodiphosphine tetradentate ligand and a ruthenium complex thereof, and preparation methods and applications of the ligand and the complex, and provides a ruthenium complex represented by a formula I, wherein L is a diaminodiphosphine tetradentate ligand represented by a formula II, and X and Y are respectively and independently chlorine ion, bromine ion, iodine ion,hydrogen negative ion or BH4. According to the present invention, the ruthenium complex exhibits excellent catalytic activity in the catalytic hydrogenation reactions of ester compounds, has high yield and high chemical selectivity, is compatible with conjugated and non-conjugated carbon-carbon double bond, carbon-carbon triple bond, epoxy, halogen, carbonyl and other functional groups, and hasgreat application prospects.
Multicatalytic Stereoselective Synthesis of Highly Substituted Alkenes by Sequential Isomerization/Cross-Coupling Reactions
Romano, Ciro,Mazet, Clément
supporting information, p. 4743 - 4750 (2018/04/10)
Starting from readily available alkenyl methyl ethers, the stereoselective preparation of highly substituted alkenes by two complementary multicatalytic sequential isomerization/cross-coupling sequences is described. Both elementary steps of these sequences are challenging processes when considered independently. A cationic iridium catalyst was identified for the stereoselective isomerization of allyl methyl ethers and was found to be compatible with a nickel catalyst for the subsequent cross-coupling of the in situ generated methyl vinyl ethers with various Grignard reagents. The method is compatible with sensitive functional groups and a multitude of olefinic substitution patterns to deliver products with high control of the newly generated C=C bond. A highly enantioselective variant of this [Ir/Ni] sequence has been established using a chiral iridium precatalyst. A complementary [Pd/Ni] catalytic sequence has been optimized for alkenyl methyl ethers with a remote C=C bond. The final alkenes were isolated with a lower level of stereocontrol. Upon proper choice of the Grignard reagent, we demonstrated that C(sp2) - C(sp2) and C(sp2) - C(sp3) bonds can be constructed with both systems delivering products that would be difficult to access by conventional methods.