5618-02-0

Basic information

• Product Name: 3-cyclopropylpropanal
• Synonyms: 3-cyclopropylpropanal;cyclopropanepropanal
• CAS NO: 5618-02-0
• Molecular Formula: C₆H₁₀O
• Molecular Weight: 98
• Mol File: 5618-02-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 136.9±9.0 °C(Predicted)
• Appearance: /
• Density: 0.937±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 3-cyclopropylpropanal(CAS DataBase Reference)
• NIST Chemistry Reference: 3-cyclopropylpropanal(5618-02-0)
• EPA Substance Registry System: 3-cyclopropylpropanal(5618-02-0)

Safety Data

• Hazardous Substances Data: 5618-02-0(Hazardous Substances Data)

Usage

General Description

3-cyclopropylpropanal is a chemical compound with the molecular formula C6H10O. It is a colorless liquid with a pungent odor, primarily used as a flavoring agent and fragrance ingredient. This chemical is commonly found in various food products, beverages, and personal care products due to its pleasant and fruity aroma. Additionally, it can also be used in the synthesis of pharmaceuticals and other organic compounds. Despite its wide range of applications, 3-cyclopropylpropanal should be handled with caution as it can cause skin and eye irritation, and it may be harmful if ingested or inhaled in large quantities.

Upstream product

• 5618-01-9 3-cyclopropyl-1-propanol 
• 862122-96-1 5-(cyclopropylmethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 821-09-0 n-Pent-4-enyl alcohol 

Downstream Products

• 582299-14-7 4-cyclopropyl-2-hydroxy-1-phenylbutan-1-one 

Relevant articles and documents

3-(2-AMINO-ETHYL)-ALKYLIDENE)-THIAZOLIDINE-2,4-DIONE AND 1-(2-AMINO-ETHYL)-ALKYLIDENE-1,3-DIHYDRO-INDOL-2-ONE DERIVATIVES AS SELECTIVE SPHINGOSINE KINASE 2 INHIBITORS

3-(2-amino-ethyl)-5-[3-(4-substituted-phenyl)-alkylidene)-thiazolidine-2,4-dione and l-(2-amino-ethyl)-3-alkylidene-l,3-dihydro-indol-2-one and derivatives thereof are provided for use as selective SphK2 inhibitors and for use in the treatment of human diseases, such as cancer.

Photochemical synthesis of highly functionalized cyclopropyl ketones

A series of di- and trisubstituted cyclopropyl ketones 11 were prepared by irradiation of ketones 3 and 5, which bear a leaving group adjacent to the carbonyl C-atom. The required ketones 3 could be easily synthesized either by functionalization of ketones 1 with a hypervalent iodine reagent, 2, or by O-sulfonylation of α-hydroxy ketones 7. The nitrates 5 were obtained by treatment of the corresponding α-bromo ketones with AgNO3. The irradiation of 3 and 5 must be performed in the presence of an acid scavenger (1-methyl-1H-imidazole) to obtain the cyclopropanes 11 in good yields. The synthetic efficiency of the method was, among other things, demonstrated by the preparation of a highly strained bicyclo[2.1.0]pentane 11i in good yield. The mechanism of the photochemical cyclization was investigated by means of photokinetic measurements, as well as by quantum-chemical calculations. It was shown that the presence of the leaving group substantially influences all steps of the photochemical reaction cascade. The X-ray crystal structures of 11j and exo-11k were also determined.