56183-38-1Relevant academic research and scientific papers
Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis
Garrison, Aaron T.,Abouelhassan, Yasmeen,Norwood, Verrill M.,Kallifidas, Dimitris,Bai, Fang,Nguyen, Minh Thu,Rolfe, Melanie,Burch, Gena M.,Jin, Shouguang,Luesch, Hendrik,Huigens, Robert W.
supporting information, p. 3808 - 3825 (2016/05/24)
Persistent bacteria, including persister cells within surface-attached biofilms and slow-growing pathogens lead to chronic infections that are tolerant to antibiotics. Here, we describe the structure-activity relationships of a series of halogenated phena
Potential chemopreventive agents based on the structure of the lead compound 2-bromo-1-hydroxyphenazine, isolated from streptomyces species, strain CNS284
Conda-Sheridan, Martin,Marler, Laura,Park, Eun-Jung,Kondratyuk, Tamara P.,Jermihov, Katherine,Mesecar, Andrew D.,Pezzuto, John M.,Asolkar, Ratnakar N.,Fenical, William,Cushman, Mark
experimental part, p. 8688 - 8699 (2011/02/28)
The isolation of 2-bromo-1-hydroxyphenazine from a marine Streptomyces species, strain CNS284, and its activity against NF-κB, suggested that a short and flexible route for the synthesis of this metabolite and a variety of phenazine analogues should be developed. Numerous phenazines were subsequently prepared and evaluated as inducers of quinone reductase 1 (QR1) and inhibitors of quinone reductase 2 (QR2), NF-κB, and inducible nitric oxide synthase (iNOS). Several of the active phenazine derivatives displayed IC50 values vs QR1 induction and QR2 inhibition in the nanomolar range, suggesting that they may find utility as cancer chemopreventive agents.
Photochemical Transformations of 5-Nitroquinoxalines
Rtishchev,Selitrenikov,El'tsov
, p. 451 - 462 (2007/10/03)
The optical and photochemical properties of 2,3,6-trimethyl-5-nitroquinoxaline have been studied. The electron transitions in the molecules of 2,3,6-trimethyl-5-nitroquinoxaline and 5-hydroxy-2,3,6-trimethylquinoxaline formed by photolysis of the nitro derivative, have been interpreted using appropriate model compounds. The spectral sensitivity of the photochemical reactions in various solvents was explained in terms of two possible mechanisms of transformation of the nitro- into hydroxyquinoxaline: photochemical nitro-nitrite rearrangement through the T1(ππ*) state (λ 313 and 334 nm) and homolytic dissociation of the Ar-NO2 bond (λ 253.7 nm). The strong increase in the quantum yield of formation of the hydroxyquinoxaline along the first mechanism on protonation of the quinoxaline nucleus has been correlated with the energy diagram of the nitroquinoxaline conjugate acid.
