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56189-68-5

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56189-68-5 Usage

Uses

CGP 13501 is a positive allosteric modulator at GABAB?receptors.

Biological Activity

Positive allosteric modulator of GABA B receptors, potentiating the effects of GABA at this receptor type.

references

[1]. urwyler s, mosbacher j, lingenhoehl k, et al. positive allosteric modulation of native and recombinant gamma-aminobutyric acid(b) receptors by 2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (cgp7930) and its aldehyde analog cgp13501. mol pharmacol, 2001, 60(5): 963-971.[2]. rasheed n, ahmad a, al-sheeha m, et al. neuroprotective and anti-stress effect of a68930 in acute and chronic unpredictable stress model in rats. neurosci lett, 2011, 504(2): 151-155.

Check Digit Verification of cas no

The CAS Registry Mumber 56189-68-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,1,8 and 9 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 56189-68:
(7*5)+(6*6)+(5*1)+(4*8)+(3*9)+(2*6)+(1*8)=155
155 % 10 = 5
So 56189-68-5 is a valid CAS Registry Number.
InChI:InChI=1/C19H30O2/c1-17(2,3)14-9-13(11-19(7,8)12-20)10-15(16(14)21)18(4,5)6/h9-10,12,21H,11H2,1-8H3

56189-68-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(3,5-di-tert-butyl-4-hydroxyphenyl)-2,2-dimethyl-propionaldehyde

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:56189-68-5 SDS

56189-68-5Downstream Products

56189-68-5Relevant articles and documents

Synthesis and biological activity of allosteric modulators of GABA B receptors, Part 2. 3-(2,6-Bis-tert-butyl-4-hydroxyphenyl)propanols

Kerr, David I. B.,Khalafy, Jabbar,Ong, Jennifer,Perkins, Michael V.,Prager, Rolf H.,Puspawati, Ni Made,Rimaz, Mehdi

, p. 457 - 462 (2007/10/03)

A series of 13 2,2-disubstituted 3-(3,5-di-t-butyl-4-hydroxyphenyl)propan- 1-ol derivatives have been prepared for evaluation as allosteric modulators of GABAB receptors. The activity (EC50, 4?7 ?M) was greatest for the cyclohexyl and cyclopentyl analogues. CSIRO 2006.

Process for preparing 3-(3,5-di-tert.alkyl-4-hydroxy-phenyl)-2,2-di-substituted propionaldehydes

-

, (2008/06/13)

There is disclosed a process comprising reacting a compound having the general structural Formula II: STR1 with a compound having the general Formula III: STR2 in the presence of a basic catalyst while dissolved in an organic solvent to yield an aldehyde

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