56189-68-5 Usage
Uses
CGP 13501 is a positive allosteric modulator at GABAB?receptors.
Biological Activity
Positive allosteric modulator of GABA B receptors, potentiating the effects of GABA at this receptor type.
references
[1]. urwyler s, mosbacher j, lingenhoehl k, et al. positive allosteric modulation of native and recombinant gamma-aminobutyric acid(b) receptors by 2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (cgp7930) and its aldehyde analog cgp13501. mol pharmacol, 2001, 60(5): 963-971.[2]. rasheed n, ahmad a, al-sheeha m, et al. neuroprotective and anti-stress effect of a68930 in acute and chronic unpredictable stress model in rats. neurosci lett, 2011, 504(2): 151-155.
Check Digit Verification of cas no
The CAS Registry Mumber 56189-68-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,1,8 and 9 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 56189-68:
(7*5)+(6*6)+(5*1)+(4*8)+(3*9)+(2*6)+(1*8)=155
155 % 10 = 5
So 56189-68-5 is a valid CAS Registry Number.
InChI:InChI=1/C19H30O2/c1-17(2,3)14-9-13(11-19(7,8)12-20)10-15(16(14)21)18(4,5)6/h9-10,12,21H,11H2,1-8H3
56189-68-5Relevant articles and documents
Synthesis and biological activity of allosteric modulators of GABA B receptors, Part 2. 3-(2,6-Bis-tert-butyl-4-hydroxyphenyl)propanols
Kerr, David I. B.,Khalafy, Jabbar,Ong, Jennifer,Perkins, Michael V.,Prager, Rolf H.,Puspawati, Ni Made,Rimaz, Mehdi
, p. 457 - 462 (2007/10/03)
A series of 13 2,2-disubstituted 3-(3,5-di-t-butyl-4-hydroxyphenyl)propan- 1-ol derivatives have been prepared for evaluation as allosteric modulators of GABAB receptors. The activity (EC50, 4?7 ?M) was greatest for the cyclohexyl and cyclopentyl analogues. CSIRO 2006.
Process for preparing 3-(3,5-di-tert.alkyl-4-hydroxy-phenyl)-2,2-di-substituted propionaldehydes
-
, (2008/06/13)
There is disclosed a process comprising reacting a compound having the general structural Formula II: STR1 with a compound having the general Formula III: STR2 in the presence of a basic catalyst while dissolved in an organic solvent to yield an aldehyde