56190-17-1

Basic information

• Product Name: 4-PROPOXY-1,2-DIAMINE BENZENE
• Synonyms: 4-PROPOXY-1,2-DIAMINE BENZENE;4-PROPOXY-1,2-DIAMINOBENZENE;4-propoxybenzene-1,2-diamine;4-Propoxy-O-Phenylenediamine;4-Propyloxy-1,2-benzenediamine;Einecs 260-044-3;4-PROXOXY-1,2-DIAMINE BENZENE;1,2-Benzenediamine, 4-propoxy-
• CAS NO: 56190-17-1
• Molecular Formula: C₉H₁₄N₂O
• Molecular Weight: 166.22
• EINECS: 260-044-3
• Product Categories: Aniline
• Mol File: 56190-17-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 324.2 °C at 760 mmHg
• Flash Point: 167.5 °C
• Appearance: /
• Density: 1.1 g/cm³
• Vapor Pressure: 0.00025mmHg at 25°C
• Refractive Index: 1.585
• Storage Temp.: 2-8°C
• PKA: 4.80±0.10(Predicted)
• CAS DataBase Reference: 4-PROPOXY-1,2-DIAMINE BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PROPOXY-1,2-DIAMINE BENZENE(56190-17-1)
• EPA Substance Registry System: 4-PROPOXY-1,2-DIAMINE BENZENE(56190-17-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22-43
• Safety Statements: 36/37
• Hazardous Substances Data: 56190-17-1(Hazardous Substances Data)

Usage

General Description

4-Propoxy-1,2-diamine benzene is a chemical compound that currently does not have much information or details available. It appears to be a benzene derivative containing amine and propoxy functional groups. Benzene is a highly stable organic compound, consisting of six carbon atoms in a planar ring structure with alternating single and double bonds, and two amine groups attached. Propoxy refers to a three-carbon chain with an oxygen atom bonded at one end. However, it is crucial to verify the structural formula and check professional databases or publishers for more detailed and valid information on this compound's properties and potential uses. Please consult a chemist for accurate information.

InChI:InChI=1/C9H14N2O/c1-2-5-12-7-3-4-8(10)9(11)6-7/h3-4,6H,2,5,10-11H2,1H3

Upstream product

• 2369-11-1 5-fluoro-2-nitroaniline 
• 113501-99-8 2-nitro-5-propoxyaniline 
• 172362-95-7 5-n-propoxy-2H-benzimidazole-2-spirocyclohexane 
• 94526-10-0 5-chloro-2H-benzimidazole-2-spirocyclohexane 
• 172362-91-3 5-Propoxy-1,3-dihydro-spiro[benzoimidazole-2,1'-cyclohexane] 

Downstream Products

• 20559-55-1 oxibendazole 
• 20559-55-1 methyl N-(6-propoxy-1H-benzimidazol-2-yl)carbamate 

Relevant articles and documents

Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization

PRMT5 plays important roles in diverse cellular processes and is upregulated in several human malignancies. Besides, PRMT5 has been validated as an anticancer target in mantle cell lymphoma. In this study, we found a potent and selective PRMT5 inhibitor by performing structure-based virtual screening and hit optimization. The identified compound 17 (IC50 = 0.33 μM) exhibited a broad selectivity against a panel of other methyltransferases. The direct binding of 17 to PRMT5 was validated by surface plasmon resonance experiments, with a Kd of 0.987 μM. Kinetic experiments indicated that 17 was a SAM competitive inhibitor other than the substrate. In addition, 17 showed selective antiproliferative effects against MV4-11 cells, and further studies indicated that the mechanism of cellular antitumor activity was due to the inhibition of PRMT5 mediated SmD3 methylation. 17 may represent a promising lead compound to understand more about PRMT5 and potentially assist the development of treatments for leukemia indications.

SYNTHESIS AND REACTIONS OF 2H-BENZIMIDAZOLE-2-SPIROCYCLOHEXANES : AN APPLICATION OF "UMPOLING"

The title compounds are available through condensation of an o-phenylenediamine with cyclohexanone followed by oxidation of the resulting product with manganese dioxide.In this article we review their oxidation, reduction, and rearrangement reactions along with their reactions with nitrogen, oxygen, sulphur, and other nucleophiles.As well as the parent compound the reactions of the 5-chloro-, 5,6-dichloro-, 4,6-dibromo-, 5-phenylsulphonyl- and 5-methoxy-derivative are discussed in some detail.Some applications of the methodology developed, particularly to the synthesis of actual or potential benzimidazole anthelminthics, are given also.