56193-21-6

Basic information

• Product Name: Cephalexin Sulfoxide
• Synonyms: Cephalexin Sulfoxide;[6R-[6α,7β(R*)]]-7-[(AMinophenylacetyl)aMino]-3-Methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid 5-Oxide;Cephalexin Sulfoxide Trifluoroacetic Acid Salt;Imp. J:Cephalexin Sulfoxide;Cefradine Impurity 2
• CAS NO: 56193-21-6
• Molecular Formula: C16H17N3O5S
• Molecular Weight: 363
• Product Categories: Amines;Chiral Reagents;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 56193-21-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: DMSO, Methanol
• Stability: Unstable in Solution
• CAS DataBase Reference: Cephalexin Sulfoxide(CAS DataBase Reference)
• NIST Chemistry Reference: Cephalexin Sulfoxide(56193-21-6)
• EPA Substance Registry System: Cephalexin Sulfoxide(56193-21-6)

Safety Data

• Hazardous Substances Data: 56193-21-6(Hazardous Substances Data)

Usage

Uses

Cephalexin sulfoxide is a derivative of Cephalexin, a Cephalosporin derivative with bactericidal activity.

Upstream product

• 15686-71-2 cefalexin 

Relevant articles and documents

Oxidation of cefalexin by permanganate: Reaction kinetics, mechanism, and residual antibacterial activity

The oxidation of cefalexin (CFX), a commonly used cephalosporin antibiotic, was investigated by permanganate (PM) in water. Apparent second-order rate constant of the reaction between CFX and PM was determined to be 12.71 ± (1.62) M-1·s-1 at neutral pH. Lower pH was favorable for the oxidation of CFX by PM. The presence of Cl- and HCO3- could enhance PM-induced oxidation of CFX, whereas HA had negligible effect on CFX oxidation by PM. PM-induced oxidation of CFX was also significant in the real wastewater matrix. After addition of bisulfite (BS), PM-induced oxidation was significantly accelerated owing to the generation of Mn(III) reactive species. Product analysis indicated oxidation of CFX to three products, with two stereoisomeric sulfoxide products and one di-ketone product. The thioether sulfur and double bond on the six-membered ring were the reactive sites towards PM oxidation. Antibacterial activity assessment indicated that the activity of CFX solution was significantly reduced after PM oxidation.