56224-53-4

Basic information

• Product Name: Hydrazine, 1,1'-(4,6-dinitro-1,3-phenylene)bis-
• CAS NO: 56224-53-4
• Molecular Formula: C6H8N6O4
• Molecular Weight: 228.167
• Mol File: 56224-53-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Hydrazine, 1,1'-(4,6-dinitro-1,3-phenylene)bis-(CAS DataBase Reference)
• NIST Chemistry Reference: Hydrazine, 1,1'-(4,6-dinitro-1,3-phenylene)bis-(56224-53-4)
• EPA Substance Registry System: Hydrazine, 1,1'-(4,6-dinitro-1,3-phenylene)bis-(56224-53-4)

Safety Data

• Hazardous Substances Data: 56224-53-4(Hazardous Substances Data)

Upstream product

• 1210-96-4 1,3-dimethoxy-4,6-dinitrobenzene 
• 2631-68-7 1,3,5-trichloro-2,4,6-trinitrobenzene 
• 3698-83-7 2,4-dichloro-1,5-dinitrobenzene 
• 64-17-5 ethanol 
• 7803-57-8 hydrazine hydrate 
• 89464-07-3 2,4,5-trinitrobromobenzene 
• 62088-24-8 1-chloro-3-hydrazino-4,6-dinitrobenzene 

Downstream Products

• 56224-55-6 1,3-diacetylhydrazino-4,6-trinitrobenzene 
• 143263-71-2 2-[(5-{N'-[1,2-Bis-ethoxycarbonyl-eth-(Z)-ylidene]-hydrazino}-2,4-dinitro-phenyl)-hydrazono]-succinic acid diethyl ester 
• 143263-59-6 2-[(5-{N'-[3-Carboxy-1-ethoxycarbonyl-prop-(Z)-ylidene]-hydrazino}-2,4-dinitro-phenyl)-hydrazono]-pentanedioic acid 1-ethyl ester 
• 143263-58-5 2-[(5-{N'-[3-Carboxy-1-methoxycarbonyl-prop-(Z)-ylidene]-hydrazino}-2,4-dinitro-phenyl)-hydrazono]-pentanedioic acid 1-methyl ester 
• 143263-56-3 2-[(5-{N'-[1,2-Bis-ethoxycarbonyl-eth-(E)-ylidene]-hydrazino}-2,4-dinitro-phenyl)-hydrazono]-succinic acid diethyl ester 
• 97541-69-0 3-[(5-{N'-[2-Methoxycarbonyl-1-(2-phenoxy-phenyl)-eth-(Z)-ylidene]-hydrazino}-2,4-dinitro-phenyl)-hydrazono]-3-(2-phenoxy-phenyl)-propionic acid methyl ester 
• 143263-60-9 2-[(5-{N'-[1,3-Bis-methoxycarbonyl-prop-(Z)-ylidene]-hydrazino}-2,4-dinitro-phenyl)-hydrazono]-pentanedioic acid dimethyl ester 
• 143263-61-0 2-[(5-{N'-[1,3-Bis-ethoxycarbonyl-prop-(Z)-ylidene]-hydrazino}-2,4-dinitro-phenyl)-hydrazono]-pentanedioic acid diethyl ester 
• 143263-57-4 2-[(5-{N'-[1,3-Dicarboxy-prop-(Z)-ylidene]-hydrazino}-2,4-dinitro-phenyl)-hydrazono]-pentanedioic acid 
• 97541-68-9 3-[(5-{N'-[2-Ethoxycarbonyl-1-phenyl-eth-(Z)-ylidene]-hydrazino}-2,4-dinitro-phenyl)-hydrazono]-3-phenyl-propionic acid ethyl ester 
• 99-65-0 meta-dinitrobenzene 

Relevant articles and documents

peri-Substituted Imidazopyridines. A New Reductive Elimination Reaction

A new reductive elimination reaction of 3,5-disubstituted imidazopyridines (3) with hydrazine is reported.Thus on treatment of the 3,5-dibromo (7a), 5-bromo-3-nitro (7b), and 3,5-dinitro (4) derivatives with hydrazine hydrate in hot ethanol, the bromine and nitro groups are replaced by hydrogen.A mechanism based on the conjugated relationship of these peri-substituents is proposed and used to explain the reported conversion of 1,3,5-trichloro-2,4,6-trinitrobenzene (9) into 1,3-dichloro-4,6-dinitrobenzene (10).A variety of other 3-nitro-5-substituted imidazopyridines (15)-(18) is described, but these could not be cyclised to 1,2,4-triazacyclopentindenes.The 3-amino-5-methoxycarbonyl derivative (19a) cyclises to the triazacyclopentindenone (20) with sodium methoxide.

Chemotherapeutically active nitro compounds. I. Nitroanilines

More than 200 nitro compounds, most of them nitroaniline derivatives substituted with one or more radicals having a basic reaction, were prepared and investigated as to their therapeutic activity against bacteria, fungi, protozoa, helminths, viruses and tumors. Several mono nitrobenzenes with a radical having a basic reaction showed a weak in vitro activity against gram positive bacteria and against Crocker's sarcoma 180; they also showed systemic activity against nematodes (Aspiculuris tetraptera) and viruses. The majority of therapeutically active compounds with pronounced in vitro activity against Trichomonas fetus, Entamoeba histolytica, Schistosoma mansoni, cestodes, nematodes (Ancylostoma caninum), viruses (influenza, MHV, SAV and EMC) and various types of carcinoma (Ehrlich's carcinoma, leukemia 1210, Crocker's sarcoma 180) were dinitrobenzene derivatives with one radical having a basic reaction and electropositive groups or unreactive or reactive chlorine atom, and di nitrobenzene with two equal or two different radicals having a basic reaction. Compound No. 70 revealed a marked in vitro activity against fungi (Trichophyton; Microsporum, Candida albicans). Other nitro compounds such as bis mono and bis dinitrobenzene derivatives likewise showed a systemic action against E. histolytica, viruses and, in particular, carcinoma (Crocker's sarcoma 180, Ridgway's osteosarcoma). Oxygen and sulfur analogue compounds as well as compounds produced by reduction also possessed a distinct activity against E. histolytica and viruses. On the basis of the present results, the dinitrobenzenes substituted with two radicals having a basic reaction include a number which have in common a recognizable structure/activity relationship in respect to E. histolytica, Schistosoma mansoni and different types of viruses. The activity against viruses in this class of compounds is probably due to an increased interferon production in the host animal. Whether the mechanism of action is the same against E. histolytica or Schistosoma mansoni has not been determined so far. A tumorigenic effect was observed mainly in those di nitrobenzenes which are classed as alkylating compounds. Because of the small chemotherapeutic index, the trials were not continued with the most effective compounds mentioned.