56227-56-6

Basic information

• Product Name: 2-(4-Benzoyl-1-piperazinyl)ethanol
• Synonyms: 2-(4-Benzoyl-1-piperazinyl)ethanol
• CAS NO: 56227-56-6
• Molecular Formula: C₁₃H₁₈N₂O₂
• Molecular Weight: 234
• Mol File: 56227-56-6.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-Benzoyl-1-piperazinyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Benzoyl-1-piperazinyl)ethanol(56227-56-6)
• EPA Substance Registry System: 2-(4-Benzoyl-1-piperazinyl)ethanol(56227-56-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 56227-56-6(Hazardous Substances Data)

Usage

General Description

2-(4-Benzoyl-1-piperazinyl)ethanol is a chemical compound that is used in pharmaceutical research and drug development. It is a derivative of piperazine and contains a benzoyl group and an ethanol group. 2-(4-Benzoyl-1-piperazinyl)ethanol has potential use as a central nervous system depressant, anesthetic, and as an antipsychotic agent. It may also have applications in the treatment of anxiety and mood disorders. Research is ongoing to explore the potential therapeutic uses of this compound and to assess its safety and efficacy for various medical conditions.

Upstream product

• 103-76-4 1-(2-hydroxyethyl)piperazine 
• 37593-94-5 4-chloro-2-nitrophenyl benzoate 
• 93-89-0 benzoic acid ethyl ester 
• 65-85-0 benzoic acid 
• 5005-35-6 2-pyridyl benzoate 
• 36228-61-2 4-(Benzoyloxy)pyridine 
• 98-88-4 benzoyl chloride 
• 35539-24-3 S-2,4-dinitrophenyl thiobenzoate 
• 1219-32-5 S-4-nitrophenyl thiobenzoate 
• 13754-38-6 N-Benzoylpiperazine 
• 959-22-8 p-nitrophenylbenzoate 
• 56227-55-5 N-benzoylpiperazine hydrochloride 
• 540-51-2 2-bromoethanol 
• 77278-38-7 4-benzoylpiperazine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1148156-72-2 C₁₃H₁₆N₂O₂ 
• 56227-57-7 (4-(2-chloroethyl)piperazin-1-yl)(phenyl)methanone 
• 104290-56-4 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-[2-(4-benzoyl-piperazin-1-yl)-ethyl] ester 5-methyl ester 
• 103-76-4 1-(2-hydroxyethyl)piperazine 
• 104329-00-2 3-Oxo-butyric acid 2-(4-benzoyl-piperazin-1-yl)-ethyl ester 

Relevant articles and documents

Design and synthesis of the 4H-chromenone derivatives against psoriasis

On basis of Quercetin moiety, two series of 20 new compounds were designed and synthesized accordingly in this study, and their anti-inflammatory activities in vitro and in vivo were evaluated. At last, compound 8A2: 3- (1- (2- (4- (5-bromo-2-chlorobenzoyl) piperazin-1-yl) ethyl)-1H-1,2,3-triazol-4-yl) methoxy)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one with low toxicity was found the best one for inhibiting of NO. Meanwhile, this compound could significantly inhibit the expression of IL-6 (Interleukin-6), TNF-α (Tumor necrosis factor-α) and IL-17 (Interleukin-17), and also significantly down-regulate IL-17 mRNA psoriasis model in vitro. Further studies were performed to establish mouse psoriasis model induced by Imiquimod (IMQ), and the preliminary mechanism indicated that compound 8A2 may alleviate mouse psoriasis through obstructed the JAK1/2-STAT1/3 pathway. This study should be provide a basis for further study of effective treatment of psoriasis.

C-3 NOVEL TRITERPENE WITH C-17 AMINE DERIVATIVES AS HIV INHIBITORS

The present invention relates to to C-3 novel triterpene with C-17 amine derivatives of formula (I); or pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, prodrugs, compositions or combination thereof, wherein R1, R2, R3, R4, R5 and 'n' are as defined herein. The present invention also relates to pharmaceutical compositions comprising compounds of formula (I) and process for preparing them, and their use for the treatment of viral diseases and particularly HIV mediated diseases.

Kinetic study on aminolysis of 2-chloro-4-nitrophenyl x-substituted-benzoates in acetonitrile and in H2O Containing 20mol% DMSO: Effects of medium and substituent X on reactivity and reaction mechanism

Second-order rate constants for reactions of 2-chloro-4-nitrophenyl X-substituted-benzoates 1a-1j with a series of cyclic secondary amines in MeCN have been measured. Comparison of the kinetic results with those reported previously for the corresponding reactions carried out in H2O containing 20 mol % DMSO has revealed that amines are less reactive in MeCN. The Bronsted-type plot for the aminolysis of 2-chloro-4-nitrophenyl benzoate (1f) in MeCN is linear with βnuc= 0.64, which is in contrast to the curved Bronsted-type plot reported for the reaction performed in the H2O-DMSO misxture. The Hammett plot for the reactions of 1a-1j with piperidine consists of two intersecting straight lines while the Yukawa-Tsuno plot exhibits an excellent linear correlation with ρX= 1.22 and r = 0.60, indicating that the nonlinear Hammett plot is not due to a change in rate-determining step but is caused by stabilization of substrates possessing an electron-donating substituent through resonance interactions between the substituent and the carbonyl functionality. It has been concluded that medium change from the H2O-DMSO mixture to MeCN forces the aminolysis of 1a-1j to proceed through a concerted mechanism by destabilizing the zwitterionic tetrahedral intermediate (T±).