5623-81-4Relevant articles and documents
Hydroformylation of 1,6-Dienes with Carbonylhydridotris(triphenylphosphine)rhodium
Grigg, Ronald,Reimer, Gerald J.,Wade, Alan R.
, p. 1929 - 1935 (1983)
Hydroformylation of a number of 1,6-dienes has been achieved at room temperature and atmospheric pressure using as catalyst.Octa-1,6-dienes are hydroformylated specifically at the terminal double bond and good selectivity for the n-aldehyde is observed when a 2:1 mixture of hydrogen and carbon monoxide are used.Both mono- and di-formyl derivatives are formed from 4,4-diacetylhepta-1,6-diene, with a strong preference for n-aldehydes.The effect of catalyst concentration on product distribution is reported.Octa-1,3,7-triene can be selectively hydroformylated by protecting the diene moiety as its cycloadduct with sulphur monoxide or dioxide, and whilst methylenecyclopentane undergoes regiospecific hydroformylation, methylenecyclobutane is isomerised to methylcyclobutene.
Iron-Catalyzed C-C Single-Bond Cleavage of Alcohols
Liu, Wei,Wu, Qiang,Wang, Miao,Huang, Yahao,Hu, Peng
supporting information, p. 8413 - 8418 (2021/11/01)
An iron-catalyzed deconstruction/hydrogenation reaction of alcohols through C-C bond cleavage is developed through photocatalysis, to produce ketones or aldehydes as the products. Tertiary, secondary, and primary alcohols bearing a wide range of substituents are suitable substrates. Complex natural alcohols can also perform the transformation selectively. A investigation of the mechanism reveals a procedure that involves chlorine radical improved O-H homolysis, with the assistance of 2,4,6-collidine.
An Engineered Alcohol Oxidase for the Oxidation of Primary Alcohols
Heath, Rachel S.,Birmingham, William R.,Thompson, Matthew P.,Taglieber, Andreas,Daviet, Laurent,Turner, Nicholas J.
, p. 276 - 281 (2019/01/04)
Structure-guided directed evolution of choline oxidase has been carried out by using the oxidation of hexan-1-ol to hexanal as the target reaction. A six-amino-acid variant was identified with a 20-fold increased kcat compared to that of the wild-type enzyme. This variant enabled the oxidation of 10 mm hexanol to hexanal in less than 24 h with 100 % conversion. Furthermore, this variant showed a marked increase in thermostability with a corresponding increase in Tm of 20 °C. Improved solvent tolerance was demonstrated with organic solvents including ethyl acetate, heptane and cyclohexane, thereby enabling improved conversions to the aldehyde by up to 30 % above conversion for the solvent-free system. Despite the evolution of choline oxidase towards hexan-1-ol, this new variant also showed increased specific activities (by up to 100-fold) for around 50 primary aliphatic, unsaturated, branched, cyclic, benzylic and halogenated alcohols.
MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF
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Paragraph 00503; 00505; 00506, (2018/11/22)
The present invention provides compounds, compositions thereof, and methods of using the same.