56239-22-6Relevant academic research and scientific papers
Synthesis and biological evaluation of new glutamic acid-based inhibitors of MurD ligase
Tomasic, Tihomir,Zidar, Nace,Rupnik, Veronika,Kovac, Andreja,Blanot, Didier,Gobec, Stanislav,Kikelj, Danijel,Masic, Lucija Peterlin
scheme or table, p. 153 - 157 (2009/05/07)
Mur ligases catalyze the biosynthesis of the UDP-MurNAc-pentapeptide precursor of peptidoglycan, an essential polymer of bacterial cell-wall. They constitute attractive targets for the development of novel antibacterial agents. Here we report on the synth
Chemistry and Antitumor Evaluation of Selected Classical 2,4-Diaminoquinazoline Analogues of Folic Acid
Hynes, J.B.,Harmon, S.J.,Floyd, G.G.,Farrington, M.,Hart, L.D.,et al.
, p. 209 - 215 (2007/10/02)
A series of six 2,4-diaminoquinazoline analogues of folic acid which bear close structural resemblance to methotrexate, 1a, were synthesized by unequivocal routes.Three of these have not been described previously, while complete structural characterizatio
