56248-16-9

Upstream product

• 80922-54-9 (E)-3-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-propensaeure-ethylester 
• 34714-43-7 [3-(2,6,6-trimethyl-1-cyclohexenyl)-2(trans)-propenyl]dimethylamine 
• 14393-44-3 (E)-3-(2,6,6-trimethylcyclohex-1-en-1-yl)prop-2-en-1-ol 
• 432-25-7 2,6,6-trimethylcyclohex-1-enecarbaldehyde 
• 51768-87-7 1-(2,2,6-trimethyl-cyclohex-1-enyl)-prop-2-en-1-ol 

Relevant academic research and scientific papers

OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE

Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.

Synthesis of CDE and BCDE molecular fragments of the limonoids havanensin and azadiradione

A new approach to the synthesis of CDE and BCDE molecular fragments of the limonoids havanensin and azadiradione has been achieved from cyclocitral and drimenal in seven steps in overall yields of 20 and 9%, respectively.