5625-62-7

Usage

Physical state

Clear and colorless liquid

Odor

Faint amine-like

Uses

+ Intermediate in the synthesis of pharmaceuticals and organic compounds
+ Corrosion inhibitor
+ Additive in cutting fluids for metalworking
+ Potential applications in the production of surfactants and polymers

Compatibility

Wide range of materials

Toxicity

Low toxicity

Industrial and research applications

Versatile and valuable chemical

Upstream product

• 4286-55-9 1-bromo-6-hexanol 
• 596810-54-7 tert-butyl 4-(6-ethoxy-6-oxo-hexyl)-1-piperazinecarboxylate 
• 110-85-0 piperazine 

Downstream Products

• 1379668-15-1 2-(4-(6-(4-tert-butylphenoxy)hexyl)piperazin-1-yl)thiazole 
• 1379668-13-9 2-(4-(6-(4-ethylphenoxy)hexyl)piperazin-1-yl)thiazole 
• 1379668-32-2 2-(4-(6-(4-isopropylphenoxy)hexyl)piperazin-1-yl)thiazole 

Relevant academic research and scientific papers

Novel substituted heteroaromatic piperazine and piperidine derivatives as inhibitors of human enterovirus 71 and coxsackievirus A16

A series of substituted heteroaromatic piperazine and piperidine derivatives were found through virtual screening based on the structure of human enterovirus 71 capsid protein VP1. The preliminary biological evaluation revealed that compounds 8e and 9e have potent activity against EV71 and Coxsackievirus A16 with low cytotoxicity.

NOVEL ARYLAMIDINE DERIVATIVE OR SALT THEREOF

An arylamidine derivative represented by a general formula described below or a salt thereof has an excellent antifungal action and high safety, and it is useful as an antifungal agent with good pharmacokinetics and pharmacodynamic properties: wherein X represents an unsubstituted or substituted lower alkylene or alkenylene group; G1 represents an oxygen atom, a sulfur atom, or an imino group; G2 represents a carbon atom or a nitrogen atom; Ra represents at least one group selected from the group consisting of a hydrogen atom, a halogen atom, and unsubstituted or substituted alkyl, cycloalkyl and alkoxy groups; R1 represents an unprotected or protected or unsubstituted or substituted amidino group; and R2 represents a substituted amino or substituted cyclic amino group, or the like.

Application of piperazine-derived hydrazone linkers for alkylation of solid-phase immobilized ketones

The preparation and application of three new solid supports with piperazine-derived hydrazine anchoring groups are described. The supports were used for immobilization of ketones. The ketones: cyclohexanone, 4-tert-butylcyclohexanone, 3-pentanone and tropinone, which were bound to polymers in the form of their hydrazones, were deprotonated with LDA and alkylated with propyl iodide or benzyl bromide. The resulting alkylated products were cleaved off the solid support on treatment with trifluoroacetic acid in dichloromethane. Linkers with 6- and 3-carbon atom spacers gave better results than the simple N-aminopiperazine linker.