56267-64-2Relevant academic research and scientific papers
CONTROLLED DRUG RELEASE FROM SOLID SUPPORTS
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Page/Page column 31-32, (2011/11/30)
The invention relates to solid supports useful in medical applications that provide controlled release of drugs, such as peptides, nucleic acids and small molecules. The drugs are covalently coupled to the solid support through a linkage that releases the drug or a prodrug through controlled beta elimination.
CONTROLLED RELEASE FROM MACROMOLECULAR CONJUGATES
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Page/Page column 24-25, (2011/11/30)
The invention relates to conjugates of macromolecular carriers and drugs comprising linkers that release the drug or a prodrug through rate-controlled beta-elimination, and methods of making and using the conjugates.
(E)-4-carboxystyrl-4-chlorobenzyl sulfone and pharmaceutical compositions thereof
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, (2008/06/13)
Pre-treatment with α,β unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone compound to a patient prior to anticancer chemotherapy with a
Styryl sulfone anticancer agents
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, (2008/06/13)
Styryl sulfone compounds of the invention selectively inhibit proliferation of tumor cells, and induce apoptosis of tumor cells, while sparing normal cells. The compounds, which are useful in the treatment of cancer and other proliferative disorders, have
Styryl sulfone anticancer agents
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, (2008/06/13)
Styryl sulfone compounds of the invention selectively inhibit proliferation of tumor cells, and induce apoptosis of tumor cells, while sparing normal cells. The compounds, which are useful in the treatment of cancer and other proliferative disorders, have
