56271-99-9Relevant articles and documents
Synthesis and utility of a novel methylene Meldrum's acid precursor
Zia-Ebrahimi,Huffman
, p. 215 - 218 (2007/10/03)
The betaine 1-[(6-hydroxy-2,2-dimethyl-4-oxo-4H-1,3-dioxin-5-yl)methyl]pyridinium hydroxide, inner salt (1), a pyridine adduct of methylene Meldrum's acid is a stable source of methylene Meldrum's acid. It is a versatile reagent which enhances the yields of Diels-Alder and Michael reactions when used instead of traditional methods that generate methylene Meldrum's acid in situ. Diels-Alder reactions performed with this reagent provide products in essentially quantitative yields. Michael reactions result in products in excess of 70% yield. This reagent provides a useful synthetic route to γ-carboxyglutamic acid.
Amino acids and peptides. 44. Synthesis of DL-gamma-carboxyglutamic acid, a new amino acid.
Weinstein,Watrin,Loie,Martin
, p. 3634 - 3635 (2007/10/13)
-