562792-74-9

Basic information

• Product Name: C₁₂H₆F₂N₂OS
• Synonyms: C₁₂H₆F₂N₂OS
• CAS NO: 562792-74-9
• Molecular Weight: 264.255
• Mol File: 562792-74-9.mol

Chemical Properties

• CAS DataBase Reference: C₁₂H₆F₂N₂OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₆F₂N₂OS(562792-74-9)
• EPA Substance Registry System: C₁₂H₆F₂N₂OS(562792-74-9)

Safety Data

• Hazardous Substances Data: 562792-74-9(Hazardous Substances Data)

Upstream product

• 40706-98-7 3,4-difluorophenacyl bromide 
• 1336804-22-8 C₁₁H₆F₂N₂S 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1336804-57-9 NSC 747414 

Relevant articles and documents

Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors

The activity of a series of imidazo[2,1-b]thiazole guanylhydrazones as inhibitors of p90 ribosomal S6 kinase 2 (RSK2) is described. It was found that a small subset of compounds show both potent inhibition of RSK2 kinase activity and tumor cell growth in vitro. Detailed study of one of the most active compounds indicates a high degree of selectivity for inhibition of RSK2 compared to a spectrum of other related kinases. Selective inhibition of the MCF-7 breast tumor cell line compared to MCF-10A non-transformed cells, as well as selective inhibition of the biomarker GSK3 provides evidence that the compounds can affect the RSK2 target in cells.