5628-70-6 Usage
Uses
Used in Organic Synthesis:
(4Z)-4-(3-iodobenzylidene)-1-(4-methylphenyl)pyrazolidine-3,5-dione is used as a synthetic intermediate for the creation of various complex organic molecules. Its iodobenzylidene group provides opportunities for cross-coupling reactions, which are essential in constructing a wide range of organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (4Z)-4-(3-iodobenzylidene)-1-(4-methylphenyl)pyrazolidine-3,5-dione is used as a potential drug candidate or pharmacological tool. (4Z)-4-(3-iodobenzylidene)-1-(4-methylphenyl)pyrazolidine-3,5-dione's pyrazolidine-3,5-dione core may endow it with biological activity, making it a valuable starting point for the development of new therapeutic agents.
Used in Drug Design and Development:
(4Z)-4-(3-iodobenzylidene)-1-(4-methylphenyl)pyrazolidine-3,5-dione is employed as a structural component in the design and development of new drugs. Its unique combination of functional groups and potential reactivity make it a versatile building block for creating novel molecules with specific biological activities.
Used in Chemical Research:
In the field of chemical research, (4Z)-4-(3-iodobenzylidene)-1-(4-methylphenyl)pyrazolidine-3,5-dione serves as a subject of study to understand its reactivity, stability, and potential applications in various chemical processes. This knowledge can be applied to optimize synthetic routes and develop new methodologies in organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 5628-70-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,6,2 and 8 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 5628-70:
(6*5)+(5*6)+(4*2)+(3*8)+(2*7)+(1*0)=106
106 % 10 = 6
So 5628-70-6 is a valid CAS Registry Number.
5628-70-6Relevant academic research and scientific papers
A Cinchona Alkaloid Antibiotic That Appears to Target ATP Synthase in Streptococcus pneumoniae
Wang, Xu,Zeng, Yuna,Sheng, Li,Larson, Peter,Liu, Xue,Zou, Xiaowen,Wang, Shufang,Guo, Kaijing,Ma, Chen,Zhang, Gang,Cui, Huaqing,Ferguson, David M.,Li, Yan,Zhang, Jingren,Aldrich, Courtney C.
, p. 2305 - 2332 (2019/04/25)
Optochin, a cinchona alkaloid derivative discovered over 100 years ago, possesses highly selective antibacterial activity toward Streptococcus pneumoniae. Pneumococcal disease remains the leading source of bacterial pneumonia and meningitis worldwide. The structure-activity relationships of optochin were examined through modification to both the quinoline and quinuclidine subunits, which led to the identification of analogue 48 with substantially improved activity. Resistance and molecular modeling studies indicate that 48 likely binds to the c-ring of ATP synthase near the conserved glutamate 52 ion-binding site, while mechanistic studies demonstrated that 48 causes cytoplasmic acidification. Initial pharmacokinetic and drug metabolism analyses of optochin and 48 revealed limitations of these quinine analogues, which were rapidly cleared, resulting in poor in vivo exposure through hydroxylation pendants to the quinuclidine and O-dealkylation of the quinoline. Collectively, the results provide a foundation to advance 48 and highlight ATP synthase as a promising target for antibiotic development.
