5628-90-0

Usage

InChI:InChI=1/C16H24N4S/c1-13(18-19-16(21)17-2)14-7-9-15(10-8-14)20-11-5-3-4-6-12-20/h7-10H,3-6,11-12H2,1-2H3,(H2,17,19,21)

Upstream product

• 21561-99-9 N-methyl-N'-phenyl-N-nitrosourea 
• 60-24-2 2-hydroxyethanethiol 
• 103-71-9 phenyl isocyanate 
• 1892-29-1 bis(2-hydroxyethyl) disulfide 
• 21597-12-6 N-phenyl-1,2,4-dithiazolidine-3,5-dione 
• 62-53-3 aniline 

Relevant academic research and scientific papers

Insights into the Mechanism of Thiol-Triggered COS/H2S Release from N-Dithiasuccinoyl Amines

The hydrolysis of carbonyl sulfide (COS) to form H2S by carbonic anhydrase has been demonstrated to be a viable strategy to deliver H2S in a biological system. Herein, we describe N-dithiasuccinoyl amines as thiol-triggered COS/H2S donors. Notably, thiol species especially GSH and homocysteine can trigger the release of both COS and H2S directly from several specific analogues via an unexpected mechanism. Importantly, two representative analogues Dts-1 and Dts-5 show intracellular H2S release, and Dts-1 imparts potent anti-inflammatory effects in LPS-challenged microglia cells. In conclusion, N-dithiasuccinoyl amine could serve as promising COS/H2S donors for either H2S biological studies or H2S-based therapeutics development.

A new one-pot synthesis of thiocarbamates from isocyanates and disulfides in the presence of Zn/AlCl3 system

A novel method has been developed for the synthesis of S-alkyl(aryl) thiocarbamates. The route involves, first, the formation of zinc thiolates by reductive cleavage of disulfides in the presence of Zn/AlCl3 system; then subsequent reaction of

Catalysis by μ-Oxo Diiron(III) Complexes of the Methanolysis of Epoxides and the Addition of Alcohols and Thiols to Phenyl Isocyanate

Carboxylate-bridged μ-oxo diiron(III) complexes of the type 1 very efficiently catalyse (a) the addition of alcohols and thiols to phenyl isocyanate and (b) the ring-opening of epoxides by methanol, with their efficiency being dependent upon the size of the group R.

N-Nitroso Compounds. IV. Reaction of N-Nitrosourea with Thiol. A New Synthesis of Thiocarbamic S-Esters

Thirteen thiocarbamic S-esters have been prepared in good yield by the reaction of thiol with substituted N-methyl-N-nitrosourea in anhydrous acetonitrile.