562826-95-3

Basic information

• Product Name: N-(3-Aminophenyl)-2-(dimethylamino)acetamide
• Synonyms: N-(3-aminophenyl)-2-(dimethylamino)acetamide;N~1~-(3-aminophenyl)-N~2~,N~2~-dimethylglycinamide(SALTDATA: 2HCl);Acetamide,N-(3-aminophenyl)-2-(dimethylamino)-;N~1~-(3-aminophenyl)-N~2~,N~2~-dimethylglycinamide
• CAS NO: 562826-95-3
• Molecular Formula: C10H15N3O
• Molecular Weight: 193.25
• Mol File: 562826-95-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 397.689°C at 760 mmHg
• Flash Point: 194.316°C
• Appearance: /
• Density: 1.171g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.617
• PKA: 14.16±0.70(Predicted)
• CAS DataBase Reference: N-(3-Aminophenyl)-2-(dimethylamino)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-Aminophenyl)-2-(dimethylamino)acetamide(562826-95-3)
• EPA Substance Registry System: N-(3-Aminophenyl)-2-(dimethylamino)acetamide(562826-95-3)

Safety Data

• Hazardous Substances Data: 562826-95-3(Hazardous Substances Data)

Usage

Description

N-(3-Aminophenyl)-2-(dimethylamino)acetamide is a chemical compound with the molecular formula C10H14N2O. It is a derivative of acetamide, containing an amino group and a dimethylamino group attached to the carbon backbone. N-(3-Aminophenyl)-2-(dimethylamino)acetamide has been studied for its potential pharmaceutical applications, particularly in the field of medicinal chemistry and drug development. Its structural features and functional groups make it a potential candidate for the synthesis of novel drugs and pharmaceutical compounds. Additionally, its unique chemical properties may also make it useful in biochemical and pharmacological research.

Uses

Used in Pharmaceutical Industry:
N-(3-Aminophenyl)-2-(dimethylamino)acetamide is used as a building block for the synthesis of novel drugs and pharmaceutical compounds due to its unique structural features and functional groups.
Used in Medicinal Chemistry Research:
N-(3-Aminophenyl)-2-(dimethylamino)acetamide is used as a research compound in medicinal chemistry to explore its potential applications in drug development and to understand its interactions with biological targets.
Used in Biochemical and Pharmacological Research:
N-(3-Aminophenyl)-2-(dimethylamino)acetamide is used in biochemical and pharmacological research to study its unique chemical properties and its potential use in the development of new therapeutic agents.

InChI:InChI=1/C10H15N3O/c1-13(2)7-10(14)12-9-5-3-4-8(11)6-9/h3-6H,7,11H2,1-2H3,(H,12,14)

Upstream product

• 99-09-2 3-nitro-aniline 
• 1232784-00-7 tert-butyl 3-(2-(dimethylamino)acetamido)phenylcarbamate 
• 294193-71-8 N,N-dimethyl-glycine-(3-nitro-anilide) 

Relevant articles and documents

SAR study on: N 2, N 4-disubstituted pyrimidine-2,4-diamines as effective CDK2/CDK9 inhibitors and antiproliferative agents

Cyclin-dependent kinases (CDKs) are pivotal kinases in cell cycle transition and gene transcription. A series of N2,N4-diphenylpyrimidine-2,4-diamines were previously identified as potent CDK2/CDK9 inhibitors. To explore the SAR of this structural prototype, twenty-four novel N2,N4-disubstituted pyrimidine-2,4-diamines were designed and synthesized. Among them, twenty-one compounds exhibited potent inhibitory activities against both CDK2/cyclin A and CDK9/cyclin T1 systems, and the most potent CDK2 and CDK9 inhibitors, 3g and 3c, showed IC50 values of 83 nM and 65 nM respectively. Most of these compounds displayed significant inhibition against the tested tumor cell lines in the SRB assay, and in particular, remained active against the triple-negative breast cancer (TNBC) cell line MDA-MB-231. Flow cytometer analysis of compounds 2a, 2d and 3b in MDA-MB-231 cells indicated that these compounds induced cell cycle arrest in G2/M phase. Docking studies on compound 3g were performed, which provided conducive clues for further molecular optimization.

PYRIMIDINE INHIBITORS OF KINASE ACTIVITY

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein G1, R2, R3, R4, R5, n, p, q, Ar1, and Ar2 are defined in the description. The present invention relates also to methods of making said compounds, and compositions comprising said compounds which are useful for inhibiting kinases such as IGF-IR.

Metasubstituted thiazolidinones, their manufacture and use as a drug

This invention involves thiazolidinone of general formula (I) and its creation and use as inhibitors of polo like kinase (PLK) for the treatment of various diseases.