562840-47-5

Basic information

• Product Name: 2,6-DIMETHOXYPYRIDINE-3-METHANOL
• Synonyms: (2,6-dimethoxypyridin-3-yl)methanol
• CAS NO: 562840-47-5
• Molecular Formula: C₈H₁₁NO₃
• Molecular Weight: 169.18
• Mol File: 562840-47-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 56-60°C
• Boiling Point: 271.2 °C at 760 mmHg
• Flash Point: >110℃
• Appearance: /
• Density: 1.17 g/cm³
• Vapor Pressure: 0.00322mmHg at 25°C
• Refractive Index: 1.523
• CAS DataBase Reference: 2,6-DIMETHOXYPYRIDINE-3-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DIMETHOXYPYRIDINE-3-METHANOL(562840-47-5)
• EPA Substance Registry System: 2,6-DIMETHOXYPYRIDINE-3-METHANOL(562840-47-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• WGK Germany: 3
• Hazardous Substances Data: 562840-47-5(Hazardous Substances Data)

Usage

General Description

2,6-DIMETHOXYPYRIDINE-3-METHANOL is a chemical compound with the molecular formula C8H11NO3. It is a derivative of pyridine and methanol, containing two methoxy groups attached to the 2 and 6 positions of the pyridine ring. 2,6-DIMETHOXYPYRIDINE-3-METHANOL is commonly used as a building block in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It may also have potential applications in the field of medicinal chemistry and drug discovery. Additionally, 2,6-DIMETHOXYPYRIDINE-3-METHANOL may exhibit various biological activities, making it of interest for further research and development in the scientific community.

InChI:InChI=1/C8H11NO3/c1-11-7-4-3-6(5-10)8(9-7)12-2/h3-4,10H,5H2,1-2H3

Upstream product

• 50-00-0 formaldehyd 
• 1188303-83-4 3-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-2,6-dimethoxypyridine 
• 221006-70-8 2,6-dimethoxypyridine-3-boronic acid 
• 562840-46-4 2,6-dimethoxynicotinic acid ethyl ester 
• 6231-18-1 2,6-dimethoxypyridine 
• 13445-16-4 3-bromo-2,6-dimethoxypyridine 
• 58819-72-0 2,6-dimethoxypyridine-3-carboxaldehyde 

Downstream Products

• 934286-66-5 C₈H₁₀NO₂Br 
• 65515-26-6 methyl 2,6-dimethoxypyridine-3-carboxylate 
• 934286-83-6 C₂₂H₃₁NO₄Si 
• 934286-75-6 C₂₂H₃₁NO₄Si 

Relevant articles and documents

Bulky N-Heterocyclic-Carbene-Coordinated Palladium Catalysts for 1,2-Addition of Arylboron Compounds to Carbonyl Compounds

The synthesis of primary, secondary, and tertiary alcohols by the 1,2-addition of arylboronic acids or boronates to carbonyl compounds, including unactivated ketones, using novel bulky yet flexible N-heterocyclic carbene (NHC)-coordinated 2,6-di(pentan-3-yl)aniline (IPent)-based cyclometallated palladium complexes (CYPs) as catalysts is reported. The PhS-IPent-CYP-catalyzed reactions are efficient at low catalyst loadings (0.02–0.3 mol% Pd), and the exceptional catalytic activity for 1,2-addition is attributed to the steric bulk of the NHC ligand. These reactions can yield a wide range of functionalized benzylic alcohols that are difficult to synthesize by classical protocols using highly active organomagnesium or lithium reagents.

Novel pyridinyl and pyrimidinylcarbazole sulfonamides as antiproliferative agents

A series of azaheterocyclic carbazole sulfonamides was synthesized and evaluated for antiproliferative activity. The most potent compounds N-(2,6-dimethoxypyridine-3-yl)-9-ethyl and 9-methylcarbazole-3-sulfonamide (13 and 14) gave significant cytotoxicity (IC50 = 122 and 101 nM). Compound 13 displayed submicromolar activities against seven human tumor cell lines. The SARs of this series of sulfonamides which includes the influence of azaheterocycle rings, sulfonamide linkage, and the carbazole ring are described.