5629-60-7 Usage
Uses
Used in Pharmaceutical Industry:
UNCARINE C is used as a pharmaceutical compound for its immunomodulating, anti-inflammatory, and anti-cancer activities. The presence of tetra/pentacyclic oxindole alkaloids in UNCARINE C contributes to its potential therapeutic applications in various diseases and conditions.
Used in Cancer Treatment:
UNCARINE C is used as an anti-cancer agent, particularly for its potential to modulate various oncological signaling pathways and exhibit inhibitory effects on tumor growth and progression. It may also demonstrate synergistic anticancer effects when combined with conventional chemotherapeutic drugs, enhancing chemo-sensitivity and efficacy in resistant cases.
Used in Drug Delivery Systems:
To improve the delivery, bioavailability, and therapeutic outcomes of UNCARINE C, novel drug delivery systems have been developed. These systems employ various organic and metallic nanoparticles as carriers for the compound, aiming to enhance its overall effectiveness in treating cancer and other related conditions.
References
Yeoh, Chan, Morsingh., Tetrahedron Lett., 931 (1966)
Chan, Morsingh, Yeoh., 1. Chem. Soc., C, 2245 (1966)
Stereochemistry:
Shamma et al., 1. Amer. Chem. Soc., 89, 1739, 2799 (1967)
Check Digit Verification of cas no
The CAS Registry Mumber 5629-60-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,6,2 and 9 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 5629-60:
(6*5)+(5*6)+(4*2)+(3*9)+(2*6)+(1*0)=107
107 % 10 = 7
So 5629-60-7 is a valid CAS Registry Number.
InChI:InChI=1/C21H24N2O4/c1-12-14-10-23-8-7-21(16-5-3-4-6-17(16)22-20(21)25)18(23)9-13(14)15(11-27-12)19(24)26-2/h3-6,11-14,18H,7-10H2,1-2H3,(H,22,25)/t12-,13-,14-,18-,21+/m0/s1
5629-60-7Relevant academic research and scientific papers
Analysis of the kinetics of isomerization of spiro oxindole alkaloids
Laus, Gerhard,Broessner, Dagmar,Senn, Gilbert,Wurst, Klaus
, p. 1931 - 1936 (2007/10/03)
The isomerization of the spiro oxindole alkaloids mitraphylline, isomitraphylline, pteropodine, isopteropodine, speciophylline and uncarine F in water has been studied at several temperatures and the rate coefficients have been determined. The effect of pH on the rate of reaction and the equilibrium composition has been investigated. The rate coefficients in water and in organic solvents correlate satisfactorily with the Dimroth-Reichardt solvent polarity parameter. The present results support the existence of a zwitterionic intermediate stabilized by polar solvents and show that protonation of the alkaloids inhibits the isomerization. The crystal structure of pteropodine has been determined.
New methods for the synthesis of oxindole alkaloids. Total syntheses of isopteropodine and pteropodine
Martin, Stephen F.,Mortimore, Michael
, p. 4557 - 4560 (2007/10/02)
The 2-oxindole alkaloids isopteropodine (11) and pteropodine (12) were conveniently synthesised from the known pentacycle (9) via a new and general protocol for oxidation and rearrangement of carboline lactams into 3,3-disubstituted-2-oxindoles.
