5630-18-2

Usage

Type of compound

boronic ester

Usage

commonly used as a reagent in organic synthesis, particularly in the Suzuki coupling reaction for forming carbon-carbon bonds

Value

unique structure makes it valuable in the creation of pharmaceuticals, agrochemicals, and materials science

Properties

stability and high reactivity

Importance

an important tool for chemists in a wide range of applications

Potential

can be used in the development of new drugs and materials due to its versatile nature and wide array of potential synthetic applications.

Upstream product

• 2113-56-6 3-methoxybiphenyl 
• 201733-56-4 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane 
• 2113-57-7 3-bromobiphenyl 
• 1057679-58-9 4-([1,1'-biphenyl]-3-yl)morpholine 

Downstream Products

• 87294-80-2 2-([1,1'-biphenyl]-3-yl)naphthalene 

Relevant academic research and scientific papers

Direct Borylation of Tertiary Anilines via C-N Bond Activation

The first successful catalytic borylation of unactivated aromatic C-N bonds of tertiary anilines without the preactivation or any directing groups is demonstrated. The reactivity of both N,N-dialkylarylamines and N-arylpyrroles were investigated systematically, and the targeted products were furnished in moderate to good yields. The DFT calculation results indicated that the catalytic cycle is furnished via a five-membered cyclic transition-state due to the steric hindrance of the Ni/NHC catalytic system.

Nickel-Catalyzed Formal Homocoupling of Methoxyarenes for the Synthesis of Symmetrical Biaryls via C-O Bond Cleavage

A new method has been developed for the nickel-catalyzed homocoupling of methoxyarenes via C-O bond cleavage using a diboron reagent. The use of 1,3-dicyclohexylimidazol-2-ylidene as a ligand was found to be critical to the success of the reaction. This new method allows the synthesis of a wide range of biaryl compounds.