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Downstream Products

• 1236202-61-1 C₂₈H₂₄ClF₃N₆O₂ 
• 1236202-60-0 C₂₇H₂₂ClF₃N₆O 
• 1236202-59-7 C₂₇H₂₂ClF₃N₆O 
• 1236202-58-6 C₁₉H₁₄ClF₃N₆O 
• 1236202-55-3 C₂₇H₂₂ClF₃N₆O₂ 
• 1236202-54-2 C₂₆H₂₀ClF₃N₆O 

Relevant academic research and scientific papers

NOVEL SPHINGOSINE 1-PHOSPHATE RECEPTOR ANTAGONISTS

The present invention relates to sphingosine-1 -phosphate (S1 P) receptors and compounds of the general formula (1), that are useful in the treatment and prevention of conditions associated with such receptors. More specifically, the present invention relates to the synthesis and use of sphingosine 1 -phosphate receptor 2 (S1 P2) antagonists that are useful in the treatment of cancer, atherosclerosis, diabetic retinopathy, and other inflammatory diseases. Among these inflammatory diseases that could be treated with these S1 P2 antagonist are those characterized by fibrosis including chronic lung disease, chronic kidney and liver disease, chronic heart disease, and skin diseases such as sclerosis/scleroderma. The S1 P2 antagonists can also be used in the treatment of glioblastoma multiforme (brain cancer), pediatric neuroblastoma, and other cancers.