56323-03-6

Basic information

• Product Name: 1-(4-HYDROXYBUTYL)-4-METHYLPIPERAZINE
• Synonyms: CHEMBRDG-BB 4014988;1-(4-HYDROXYBUTYL)-4-METHYLPIPERAZINE;1-Piperazinebutanol,4-methyl-(6CI,9CI);1-(4-HYDROXYBUTYL)-4-METHYL-PIPERAZINE >98%;4-(4-methylpiperazin-1-yl)butan-1-ol(SALTDATA: FREE)
• CAS NO: 56323-03-6
• Molecular Formula: C₉H₂₀N₂O
• Molecular Weight: 172.27
• Product Categories: PIPERIDINE;piperazines
• Mol File: 56323-03-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 88-90°C 0,2mm
• Flash Point: 116.3 °C
• Appearance: /
• Density: 0.975 g/cm³
• Vapor Pressure: 0.000975mmHg at 25°C
• Refractive Index: 1.482
• Storage Temp.: 2-8°C
• PKA: 15.16±0.10(Predicted)
• CAS DataBase Reference: 1-(4-HYDROXYBUTYL)-4-METHYLPIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-HYDROXYBUTYL)-4-METHYLPIPERAZINE(56323-03-6)
• EPA Substance Registry System: 1-(4-HYDROXYBUTYL)-4-METHYLPIPERAZINE(56323-03-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 56323-03-6(Hazardous Substances Data)

Usage

General Description

1-(4-HYDROXYBUTYL)-4-METHYLPIPERAZINE, also known as 4-(4-HYDROXYBUTYL)-1-METHYLPIPERAZINE or 4-Methyl-1-(4-hydroxybutyl)piperazine, is a chemical compound with a molecular formula C9H20N2O. It is a piperazine derivative with a hydroxybutyl group attached to the nitrogen atom. 1-(4-HYDROXYBUTYL)-4-METHYLPIPERAZINE has potential pharmaceutical applications and is used in the synthesis of various drugs and pharmaceutical products. It may also be used as a building block in organic synthesis and chemical research. Overall, 1-(4-HYDROXYBUTYL)-4-METHYLPIPERAZINE is a versatile chemical with potential applications in pharmaceuticals, research, and industry.

InChI:InChI=1/C9H20N2O/c1-10-5-7-11(8-6-10)4-2-3-9-12/h12H,2-9H2,1H3

Upstream product

• 109-01-3 1-methyl-piperazine 
• 928-51-8 4-Chloro-1-butanol 
• 302801-82-7 4-(4-methyl-1-piperazinyl)butyl acetate 

Downstream Products

• 102450-44-2 1-(4-chloro-butyl)-4-methyl-piperazine; dihydrochloride 
• 127976-27-6 3-Methoxymethoxy-5-methyl-2'-nitro-biphenyl-2,6-dicarboxylic acid 2-methyl ester 6-[4-(4-methyl-piperazin-1-yl)-butyl] ester 
• 127976-88-9 5-Hydroxy-3-methyl-2'-nitro-biphenyl-2,6-dicarboxylic acid 6-methyl ester 2-[4-(4-methyl-piperazin-1-yl)-butyl] ester; hydrochloride 

Relevant articles and documents

Piperazinylalkyl prodrugs of naproxen improve in vitro skin permeation

Novel morpholinyl (4a) and piperazinylalkyl (4b-e) esters were synthesized and evaluated in vitro for their properties as bioreversible topically administered dermal prodrugs of naproxen. These ionizable prodrugs exhibited various aqueous solubilities and lipophilicities, depending on the pH of medium. As indicated by octanol-buffer partition coefficients (logP(app)) at pH 7.4, all of the prodrugs were significantly more lipophilic (logP(app)=0.7-3.9) than naproxen (logP(app)=0.3). Furthermore, the most aqueous of the soluble prodrugs (4b-d) were only 2-3-fold less soluble in an aqueous buffer of pH 7.4 (~30-50 mM) than was naproxen (~100 mM). At a pH of 5.0, prodrugs showed a generally higher aqueous solubility and similar logP(app) values, compared to naproxen. The chemical and enzymatic hydrolysis of prodrugs at 37°C was investigated in aqueous buffer solutions (pH 5.0 and 7.4) and in 80% human serum (pH 7.4), respectively. The prodrugs showed moderate chemical stability (t(1/2)=15-150 days at pH 5.0), and they were hydrolyzed enzymatically to naproxen, with half-lives ranging from 0.4 to 77 min. In permeation studies using post-mortem human skin in vitro, the flux of naproxen was 6.5 and 1.6 nmol/cm2.h in a saturated aqueous buffer vehicle of pH 7.4 and 5.0, respectively. Among the prodrugs, two piperazinyl derivatives (4c and 4d) resulted in a 9- and 4-fold enhancement of permeation, respectively, when compared to naproxen itself at pH 7.4. 4c also resulted in a significantly (4-fold) better permeation than naproxen at pH 5.0. In conclusion, piperazinyl esters improved skin permeation of naproxen and are promising prodrugs of naproxen for topical drug delivery. Copyright (C) 2000 Elsevier Science B.V.