56341-36-7

Usage

Uses

1. Used in Pharmaceutical Applications:
1,5-DIMETHYL-2-PYRROLECARBONITRILE is used as a pro-apoptotic and antitumor agent for its potential to induce cell death and inhibit tumor growth.
2. Used in Chemical Research:
1,5-DIMETHYL-2-PYRROLECARBONITRILE serves as a subject of study in chemical research, particularly in understanding its standard molar enthalpy of formation in the gaseous phase, which can provide insights into its properties and potential applications in various industries.

InChI:InChI=1/C7H8N2/c1-6-3-4-7(5-8)9(6)2/h3-4H,1-2H3

Upstream product

• 142057-56-5 4-bromo-1,5-dimethyl-1H-pyrrole-2-carbonitrile 
• 22083-74-5 3-(1-methyl-pyrrolidin-2-yl)-pyridine 

Downstream Products

• 118799-24-9 2-aminomethyl-1,5-dimethylpyrrole 
• 1193-59-5 1,5-dimethyl-1H-pyrrole-2-carbaldehyde 
• 158773-71-8 5-(1,5-dimethyl-2-pyrrolyl)tetrazole 
• 26171-22-2 1-Methyl-5-(4-methylbenzoyl)pyrrole-2-acetonitrile 
• 1112971-69-3 (CO)5W((CH₃)3Si)2CHPC(C₆H₅)NC(C₄H₂N(CH₃)2)N 
• 942612-13-7 1-(2-methyl-5-(4-methoxyphenyl)-3-thienyl)-2-(2-cyano-1,5-dimethyl-4-pyrryl)hexafluorocyclopentene 
• 1607454-75-0 1-(1,5-dimethyl-1H-pyrrol-2-yl)-5-hydroxy-2-phenylpentan-1-one 
• 1607454-76-1 1-(1,5-dimethyl-1H-pyrrol-2-yl)-5-hydroxy-2-(naphthalen-2-yl)pentan-1-one 
• 1607454-77-2 2-([1,1'-biphenyl]-4-yl)-1-(1,5-dimethyl-1H-pyrrol-2-yl)-5-hydroxypentan-1-one 
• 1617529-35-7 benzyl-[3-(1,5-dimethyl-1H-pyrrol-2-yl)-5-methyl-isoquinolin-1-yl]-amine 
• 565191-91-5 4-formyl-1,5-dimethylpyrrole-2-carbonitrile 
• 174151-06-5 1,5-Dimethyl-1H-pyrrole-2-carboxamide 
• 134790-05-9 2-(1,5-Dimethyl-1H-pyrrol-2-yl)-4,5-bis-(4-methylsulfanyl-phenyl)-thiazole 
• 134790-04-8 4,5-Bis(4-methoxyphenyl)-2-(1,5-dimethyl-2-pyrrolyl)thiazole 

Relevant academic research and scientific papers

Interconversion of nicotine enantiomers during heating and implications for smoke from combustible cigarettes, heated tobacco products, and electronic cigarettes

Physiological properties of (R)-nicotine have differences compared with (S)-nicotine, and the subject of (S)- and (R)-nicotine ratio in smoking or vaping related items is of considerable interest. A Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (LC-MS/MS) method for the analysis of (S)- and (R)-nicotine has been developed and applied to samples of nicotine from different sources, nicotine pyrolyzates, several types of tobacco, smoke from combustible cigarettes, smoke from heated tobacco products, e-liquids, and particulate matter obtained from e-cigarettes aerosol. The separation was achieved on a Chiracel OJ-3 column, 250 × 4.6 mm with 3-μm particles using a nonaqueous mobile phase. The detection was performed using atmospheric pressure chemical ionization (APCI) in positive mode. The only transition measured for the analysis of nicotine was 163.1 → 84.0. The method has been summarily validated. For the analysis, the samples of tobacco and smoke from combustible cigarettes were subject to a cleanup procedure using solid phase extraction (SPE). It was demonstrated that nicotine upon heating above 450°C for several minutes starts decomposing, and some formation of (R)-enantiomer from a sample of 99% (S)-nicotine is observed. An analogous process takes place when a 99% (R)-nicotine is heated and forms low levels of (S)-nicotine. This interconversion has the effect of slightly increasing the content of (R)-nicotine in smoke compared with the level in tobacco for combustible cigarettes and for heated tobacco products. The (S)/(R) ratio of nicotine enantiomers in e-liquids was identical with the ratio for the particulate phase of aerosols generated by e-cigarette vaping.

Synthesis and photochromic behaviour of new dipyrrolylperfluorocyclopentenes

The synthesis of new photoswitchable dipyrrolylethenes having different π-conjugated chain lengths, employing Wittig-Horner reaction, Knoevenagel condensation, Suzuki palladium catalyzed cross-coupling or Sonogashira coupling, is reported. Their photochemical behaviour, and in particular, their thermal stability has been investigated upon continuous irradiation with light of appropriate wavelengths.