56348-67-5Relevant academic research and scientific papers
Synthesis of enantiomerically enriched-bromonitriles from amino acids
Tka, Najeh,Kraem, Jamil,Hassine, Bechir Ben
, p. 735 - 743 (2013/01/15)
Two methods were investigated for the preparation of six chiral-bromonitriles with different optic purities. The nitrous deamination of amino acids gives-bromoacids, which react with chlorosulfonyl isocyanate followed by triethylamine to afford-bromonitriles with moderate enantiomeric excess. However, the dehydration of corresponding-bromoamids using thionyl chloride gives-bromonitriles with good enantiomeric excess up to 94%. The use of phosphoryl chloride instead of thionyl chloride results in more than 30% racemization as determined by high-performance liquid chromatograpic analysis.
Combinatorial dihydrobenzopyran library
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, (2008/06/13)
Combinatorial libraries are disclosed which are represented by Formula I: wherein: S is a solid support; T'--L-- is an identifier residue; and --L'--II' is a ligand/linker residue. These libraries contain dihydrobenzopyrans of the formula: STR1 which interact (i.e., as agonists or antagonists) with α adrenergic receptors, dopamine receptors, ?-opiate receptors, and K+ channels and are inhibitors of carbonic anhydrase isozymes. They are useful in the treatment of ocular diseases such as glaucoma.
REACTIONS OF ARYLDIAZONIUM TETRAFLUOROBORATES WITH ACRYLAMIDE IN THE PRESENCE OF THIOCYANATES, BROMIDES, AND CHLORIDES OF ALKALI METALS AND AMMONIUM
Grishchuk, B. D.,Gorbovoi, P. M.,Kudrik, E. Ya.,Ganushchak, N. I.
, p. 1620 - 1623 (2007/10/02)
The reaction of aryldiazonium tetrafluoroborates with acrylamide in a water-acetone mixture (1:2) in the presence of copper or iron salts and additives of thiocyanates (bromides, chlorides) of alkali metals and ammonium yields α-thiocyanato(bromo, chloro)-β-arylpropionamides. These compounds under the action of triethylamine easily eliminate hydrogen thiocyanate (bromide, chloride) with formation of β-arylacrylamides.
