56355-79-4

Basic information

• Product Name: Ethyl 2-(2-bromo-1,3-thiazol-4-yl)acetate
• Synonyms: Ethyl 2-(2-bromo-1,3-thiazol-4-yl)acetate;ethyl 2-(2-bromothiazol-4-yl)acetate;2-BroMo-4-thiazoleacetic acid ethyl ester;(2-Bromo-thiazol-4-yl)-acetic acid ethyl ester
• CAS NO: 56355-79-4
• Molecular Formula: C₇H₈BrNO₂S
• Molecular Weight: 250.12
• Mol File: 56355-79-4.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 291.902 °C at 760 mmHg
• Flash Point: 130.338 °C
• Appearance: /
• Density: 1.587 g/cm³
• CAS DataBase Reference: Ethyl 2-(2-bromo-1,3-thiazol-4-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-(2-bromo-1,3-thiazol-4-yl)acetate(56355-79-4)
• EPA Substance Registry System: Ethyl 2-(2-bromo-1,3-thiazol-4-yl)acetate(56355-79-4)

Safety Data

• Hazardous Substances Data: 56355-79-4(Hazardous Substances Data)

Usage

General Description

Ethyl 2-(2-bromo-1,3-thiazol-4-yl)acetate is a chemical compound with the molecular formula C8H8BrNO2S that is commonly used in organic synthesis and pharmaceutical research. It is an ester derivative of 2-(2-bromo-1,3-thiazol-4-yl)acetic acid, and is often used as an intermediate in the production of various pharmaceuticals and organic compounds. Ethyl 2-(2-bromo-1,3-thiazol-4-yl)acetate is known for its diverse range of applications, including its use as a building block for the synthesis of various heterocyclic compounds. Additionally, it is utilized for its potential pharmacological properties, making it a valuable chemical in the field of medicinal chemistry.

Upstream product

• 53266-94-7 ethyl 2-amino-1,3-thiazol-4-acetate 

Downstream Products

• 263169-24-0 2-(2-bromothiazol-4-yl)ethanol 
• 917023-38-2 [2-(4-{1-ethyl-1-[3-methyl-4-((E)-4,4,4-trifluoro-3-hydroxy-3-trifluoromethyl-1-butenyl)-phenyl]-propyl}-2-methyl-phenyl)-thiazol-4-yl]-acetic acid 
• 917023-31-5 [2-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethylpentyl)-3-methyl-phenyl]-propyl}-2-methyl-phenyl)-thiazol-4-yl]-acetic acid 
• 917023-25-7 [2-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethylpentyl)-3-methyl-phenyl]-propyl}-2-methyl-phenyl)-thiazol-4-yl]-acetic acid 
• 1579295-09-2 ethyl 2-(2-(4-phenylbut-1-ynyl)thiazol-4-yl)acetate 
• 1579293-84-7 N-hydroxy-2-(2-(4-phenylbutyl)thiazol-4-yl)acetamide 
• 1579295-11-6 2-(2-(4-phenylbutyl)thiazol-4-yl)acetic acid 
• 1579295-10-5 ethyl 2-(2-(4-phenylbutyl)thiazol-4-yl)acetate 
• 917025-34-4 {2-[4-(1-{4-[3-(t-butyl-dimethyl-silanyloxy)-4,4-dimethyl-pentyl]-3-methyl-phenyl}-1-ethyl-propyl)-2-methyl-phenyl]-thiazol-4-yl}-acetic acid ethyl ester 
• 917025-25-3 {2-[4-(1-{4-[3-(t-butyl-dimethyl-silanyloxy)-4,4-dimethyl-pentyl]-3-methyl-phenyl}-1-ethyl-propyl)-2-methyl-phenyl]-thiazol-4-yl}-acetic acid ethyl ester 
• 917025-42-4 [2-(4-{1-ethyl-1-[3-methyl-4-((E)-4,4,4-trifluoro-3-hydroxy-3-trifluoromethyl-1-butenyl)-phenyl]-propyl}-2-methyl-phenyl)-thiazol-4-yl]-acetic acid ethyl ester 
• 913650-49-4 ethyl [2-(5-chloro-2-{[(4-fluorophenyl)methyl]oxy}phenyl)-1,3-thiazol-4-yl]acetate 
• 7504-44-1 thiazol-4-yl acetic acid 
• 120155-43-3 thiazol-4-yl acetic acid ethyl ester 

Relevant articles and documents

4-(2-chloroethyl) thiazole-2-carboxylic acid ethyl ester and preparation method and application thereof

The invention provides 4-(2-chloroethyl) thiazole-2-carboxylic acid ethyl ester and a preparation method and application thereof. The preparation method comprises the steps that 2-(2-aminothiazole-4-yl) ethyl acetate of a compound 1 is dissolved in dichloromethane, and 2-(2-bromothiazole-4-yl) ethyl acetate is obtained through diazotization and halogenation; then, under the condition of a reducing agent, 2-(2-bromothiazole-4-yl) ethane-1-ol is obtained; in a carbon monoxide atmosphere, carbonyl insertion reaction is performed through a proper catalyst to obtain 4-(2-ethoxyl) thiazole-2-carboxylic acid ethyl ester; and finally, thionyl chloride is used for chlorination to obtain 4-(2-chloroethyl) thiazole-2-carboxylic acid ethyl ester. The 4-(2-chloroethyl) thiazole-2-carboxylic acid ethyl ester can be used as an intermediate in synthesis of APJ receptor stimulant compounds. The invention provides a route method for synthesizing the 4-(2-chloroethyl) thiazole-2-carboxylic acid ethyl ester for the first time, the reaction condition is mild after the brominating reagent is optimized in the first step, and the yield is improved.

Oxazolidinone compounds and its use in medicine

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