5636-92-0

Basic information

• Product Name: picloxydine
• Synonyms: picloxydine;N,N''-Bis[[(4-chlorophenyl)amino](imino)methyl]-1,4-piperazinebiscarbimide amide;N,N''-Bis[4-chlorophenylamino(imino)methyl]-1,4-piperazinebiscarbimide amide
• CAS NO: 5636-92-0
• Molecular Formula: C₂₀H₂₄Cl₂N₁₀
• Molecular Weight: 475.386
• EINECS: 227-084-3
• Mol File: 5636-92-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 703.8°Cat760mmHg
• Flash Point: 379.5°C
• Appearance: /
• Density: 1.5g/cm³
• Vapor Pressure: 1.17E-19mmHg at 25°C
• Refractive Index: 1.717
• PKA: 11?+-.0.20(Predicted)
• CAS DataBase Reference: picloxydine(CAS DataBase Reference)
• NIST Chemistry Reference: picloxydine(5636-92-0)
• EPA Substance Registry System: picloxydine(5636-92-0)

Safety Data

• Hazardous Substances Data: 5636-92-0(Hazardous Substances Data)

Usage

Uses

Picloxydine is a known antiseptic agent which also carries properties on cholinesterase inhibition.

InChI:InChI=1/C20H24Cl2N10/c21-13-1-5-15(6-2-13)27-17(23)29-19(25)31-9-11-32(12-10-31)20(26)30-18(24)28-16-7-3-14(22)4-8-16/h1-8H,9-12H2,(H4,23,25,27,29)(H4,24,26,28,30)

Upstream product

• 110-85-0 piperazine 
• 1482-62-8 1-(4-chlorophenyl)-3-cyanoguanidine 
• 106-47-8 4-chloro-aniline 

Relevant articles and documents

Repurposing N,N'-bis-(arylamidino)-1,4-piperazinedicarboxamidines: An unexpected class of potent inhibitors of cholinesterases

Drug repurposing (=drug repositioning) is an effective way to cut costs for the development of new therapeutics and to reduce the time-to-market time-span. Following this concept a small library of compounds was screened for their ability to act as inhibitors of acetyl- and butyrylcholinesterase. Picloxydine, an established antiseptic, was shown to be an inhibitor for both enzymes. Systematic variation of the aryl substituents led to analogs possessing almost the same good properties as gold standard galantamine hydrobromide.