56367-27-2

Basic information

• Product Name: 2-(sec-butyl)-4,5-dihydrothiazole
• Synonyms: 2-(sec-butyl)-4,5-dihydrothiazole;4,5-Dihydro-2-(1-methylpropyl)thiazole;Thiazole, 4,5-dihydro-2-(1-methylpropyl)-
• CAS NO: 56367-27-2
• Molecular Formula: C7H13 N S
• Molecular Weight: 143.25
• Mol File: 56367-27-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 193°C at 760 mmHg
• Flash Point: 70.5°C
• Appearance: /
• Density: 1.06g/cm³
• Vapor Pressure: 0.661mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: 2-8°C
• PKA: 4.97±0.10(Predicted)
• CAS DataBase Reference: 2-(sec-butyl)-4,5-dihydrothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(sec-butyl)-4,5-dihydrothiazole(56367-27-2)
• EPA Substance Registry System: 2-(sec-butyl)-4,5-dihydrothiazole(56367-27-2)

Safety Data

• Hazardous Substances Data: 56367-27-2(Hazardous Substances Data)

Usage

General Description

2-(sec-butyl)-4,5-dihydrothiazole is a chemical compound with the molecular formula C7H13NS. It is classified as a thiazole, which is a five-membered ring containing sulfur and nitrogen atoms. 2-(sec-butyl)-4,5-dihydrothiazole is commonly used in the fragrance industry as a synthetic musk, adding a woody or fruity note to perfumes and personal care products. It is characterized by its strong, long-lasting odor and is often used in combination with other aromatic compounds to create complex and unique scents. Additionally, 2-(sec-butyl)-4,5-dihydrothiazole is also used as a flavoring agent in food products, contributing to the overall taste and aroma of various consumables.

InChI:InChI=1/C7H13NS/c1-3-6(2)7-8-4-5-9-7/h6H,3-5H2,1-2H3

Upstream product

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Relevant articles and documents

Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors

Innate behaviors are genetically encoded, but their underlying molecular mechanisms remain largely unknown. Predator odor 2,4,5-trimethyl-3-thiazoline (TMT) and its potent analog 2-methyl-2-thiazoline (2MT) are believed to activate specific odorant receptors to elicit innate fear/defensive behaviors in naive mice. Here, we conduct a large-scale recessive genetics screen of ethylnitrosourea (ENU)-mutagenized mice. We find that loss of Trpa1, a pungency/irritancy receptor, diminishes TMT/2MT and snake skin-evoked innate fear/defensive responses. Accordingly, Trpa1 -/- mice fail to effectively activate known fear/stress brain centers upon 2MT exposure, despite their apparent ability to smell and learn to fear 2MT. Moreover, Trpa1 acts as a chemosensor for 2MT/TMT and Trpa1-expressing trigeminal ganglion neurons contribute critically to 2MT-evoked freezing. Our results indicate that Trpa1-mediated nociception plays a crucial role in predator odor-evoked innate fear/defensive behaviors. The work establishes the first forward genetics screen to uncover the molecular mechanism of innate fear, a basic emotion and evolutionarily conserved survival mechanism.