56388-02-4

Basic information

• Product Name: 5-Benzoxazolecarboxylicacid,2-amino-,methylester(9CI)
• Synonyms: 5-Benzoxazolecarboxylicacid,2-amino-,methylester(9CI)
• CAS NO: 56388-02-4
• Molecular Formula: C₉H₈N₂O₃
• Molecular Weight: 192.17
• Product Categories: AMINOACID
• Mol File: 56388-02-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 238 °C(Solv: ethanol (64-17-5))
• Boiling Point: 352.6±34.0 °C(Predicted)
• Appearance: /
• Density: 1.375±0.06 g/cm3(Predicted)
• PKA: -1.03±0.10(Predicted)
• CAS DataBase Reference: 5-Benzoxazolecarboxylicacid,2-amino-,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Benzoxazolecarboxylicacid,2-amino-,methylester(9CI)(56388-02-4)
• EPA Substance Registry System: 5-Benzoxazolecarboxylicacid,2-amino-,methylester(9CI)(56388-02-4)

Safety Data

• Hazardous Substances Data: 56388-02-4(Hazardous Substances Data)

Upstream product

• 536-25-4 methyl 3-amino-4-hydroxybenzoate 
• 104619-51-4 di(1H-imidazol-1-yl)methanimine 
• 506-68-3 bromocyane 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 99-42-3 methyl (4-hydroxy-3-nitro)benzoate 

Downstream Products

• 56350-69-7 1-(2-amino-benzooxazole-5-carbonyl)-4-phenyl-thiosemicarbazide 

Relevant articles and documents

ANTIBACTERIAL PICOLINAMIDE COMPOUNDS

Here we report the discovery of 2-(4-(3-(trifluoromethoxy)phenoxy)picolinamido) benzo[d]oxazole-5-carboxylate as an antibacterial with potent and selective activity against C. difficile. Its MIC50 andMIC90 values,documented across 101 strains of C. difficile, are 0.12 and 0.25 μg/mL, respectively. The compound is effective against C. difficile both at the logarithmic (vegetative) and stationary phases of growth. It targets cell-wall biosynthesis, as assessed both by macromolecular biosynthesis assays and by scanning-electron microscopy. Animals infected with a lethal dose of C. difficile and treated with compound 1 had better survival compared to treatment with vancomycin, which is the front-line antibiotic used for severe recurrent C. difficile infection.

Synthesis and biological activities of some Novel 2-Amino-(5 or 7-Substituted- 2-Oxoindolin-3-Ylidene) Benzoxazole-5-Carbohydrazide derivatives

A series of 2-amino-(5 or 7-substituted-2-oxoindolin-3-ylidene) benzoxazole-5-carbohydrazide derivatives were synthesized by treating 2-aminobenzoxazole-5-carbohydrazide with different substituted isatins. All the synthesized derivatives (VI a-l) were screened for their in vitro anticancer (against HeLa, IMR-32 & MCF-7 cancer cell lines), antioxidant (against DPPH radicals) and antimicrobial activities. The results of these studies showed the dose dependant anticancer, antioxidant and antimicrobial activities of the test compounds and the IC50 values of some compounds were comparable with their standard agent. The test compounds having substitution with different electron withdrawing groups at C-5 position showed more potent anticancer, antioxidant and antibacterial activities than those at C-7 position.

Derivatives of 2 aminooxazole and 2 iminooxazoline. VIII

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