56417-19-7Relevant academic research and scientific papers
Antihypertensive Ureidopiperidines
Archibald, J. L.,Beardsley, D. R.,Bisset, G. M. F.,Fairbrother, P.,Jackson, J. L.,et al.
, p. 857 - 861 (2007/10/02)
The synthesis of a series of 1-aralkyl-4-ureidopiperidines is reported.These compounds are related to the benzamidopiperidines exemplified by indoramin.Some of the ureidopiperidines are more potent antihypertensive agents than their benzamidopiperidine co
1-[(3-Indolyl)-alkyl]-piperidyl ureas and hypotensive compositions
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, (2008/06/13)
The invention provides compounds of general formula I STR1 and pharmaceutically acceptable acid addition and quaternary ammonium salts thereof, wherein R represents hydrogen or lower alkyl, R1 represents hydrogen or lower alkyl, R2 represents hydrogen or lower alkyl, R3 represents hydrogen, halogen, lower alkoxy, hydroxy, or lower alkyl, R4 represents hydrogen, lower alkyl, cycloalkyl of 5 to 7 carbon atoms, thienyl, furyl, phenyl; phenyl mono- or disubstituted by halogen, lower alkyl, lower alkoxy, hydroxy or trifluoromethyl; or benzoyl, halobenzoyl, lower alkanoyl, cycloalkanoyl of 6 to 8 carbon atoms, or thienoyl, A represents an alkylene, mono- or diketo- or hydroxy-alkylene radical having from 1 to 5 carbon atoms and X is oxygen or sulphur. The compounds exhibit action on the cardiovascular system particularly hypotensive and/or anti-hypertensive activity.
Ureidopiperidino-ketoalkyl indoles
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, (2008/06/13)
The invention provides compounds of general formula I STR1 and pharmaceutically acceptable acid addition and quaternary ammonium salts thereof, wherein R represents hydrogen or lower alkyl, R1 represents hydrogen or lower alkyl, R2 represents hydrogen or lower alkyl, R3 represents hydrogen, halogen, lower alkoxy, hydroxy, or lower alkyl, R4 represents hydrogen, lower alkyl, cycloalkyl of 5 to 7 carbon atoms, thienyl, furyl, phenyl; phenyl mono- or disubstituted by halogen, lower alkyl, lower alkoxy, hydroxy or trifluoromethyl; or benzoyl, halobenzoyl, lower alkanoyl, cycloalkanoyl of 6 to 8 carbon atoms, or thienoyl, A represents an alkylene, mono- or diketo- or hydroxy-alkylene radical having from 1 to 5 carbon atoms and X is oxygen or sulphur. The compounds exhibit action on the cardiovascular system particularly hypotensive and/or anti-hypertensive activity.
