56421-62-6

Basic information

• Product Name: ETHYL 4-METHYL-2-(2-THIENYL)-1,3-THIAZOLE-5-CARBOXYLATE
• Synonyms: ETHYL 4-METHYL-2-(2-THIENYL)-1,3-THIAZOLE-5-CARBOXYLATE;ethyl 4-methyl-2-(2-thienyl)-thiazole-5 Carboxylate;4-methyl-2-(2-thienyl)-5-Thiazolecarboxylic acid ethyl ester
• CAS NO: 56421-62-6
• Molecular Formula: C11H11NO2S2
• Molecular Weight: 253.34
• Mol File: 56421-62-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 66-68°C
• Boiling Point: 380.9°Cat760mmHg
• Flash Point: 184.1°C
• Appearance: /
• Density: 1.282g/cm³
• Vapor Pressure: 5.29E-06mmHg at 25°C
• Refractive Index: 1.592
• PKA: 1.26±0.10(Predicted)
• CAS DataBase Reference: ETHYL 4-METHYL-2-(2-THIENYL)-1,3-THIAZOLE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-METHYL-2-(2-THIENYL)-1,3-THIAZOLE-5-CARBOXYLATE(56421-62-6)
• EPA Substance Registry System: ETHYL 4-METHYL-2-(2-THIENYL)-1,3-THIAZOLE-5-CARBOXYLATE(56421-62-6)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 56421-62-6(Hazardous Substances Data)

Usage

Description

ethyl 4-methyl-2-(2-thienyl)-thiazole-5 Carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.

Uses

Ethyl4-Methyl-2-(thiophen-2-yl)thiazole-5-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.

InChI:InChI=1/C11H11NO2S2/c1-3-14-11(13)9-7(2)12-10(16-9)8-5-4-6-15-8/h4-6H,3H2,1-2H3

Upstream product

• 188290-36-0 thiophene 
• 100289-17-6 1-(2-Amino-4-methyl-5-thiazolyl)-1-propanon 
• 20300-02-1 thiophene-2-carbothioamide 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 5813-89-8 2-thiophenylcarboxamide 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 

Relevant articles and documents

Synthesis and antimicrobial study of thiophene clubbed thiazolyl carbohydrazides

Thiophene containing thiazolyl carbohydrazide on reaction with various aryl isothiocynates yields thiosemicarbazides which were transformed into 1,2,4-substituted thiazoles by Hantzsch synthesis and characterized by spectral methods. Most of the synthesiz

2-substitution-4-methyl-5-(4, 5-thiazoline-2-base)-1, 3-thiazole compound, method for preparing same and evaluation of biological activity

The invention belongs to the field of technologies for chemically synthesizing thiazole derivatives and evaluating the biological activity, and relates to a 2-substitution-4-methyl-5-(4, 5-thiazoline-2-base)-1, 3-thiazole compound shown as a formula I, and further provides a method for preparing 2-substitution-4-methyl-5-(4, 5-thiazoline-2-base)-1, 3-thiazole and evaluation of the biological activity for inhibiting the activity of urease and inhibiting the activity of Escherichia coli, Bacillus subtilis and Staphylococcus aureas. The 2-substitution-4-methyl-5-(4, 5-thiazoline-2-base)-1, 3-thiazole compound, the method and the evaluation have the advantages that the 2-substitution-4-methyl-5-(4, 5-thiazoline-2-base)-1, 3-thiazole compound has certain biological activity, and accordingly the 2-substitution-4-methyl-5-(4, 5-thiazoline-2-base)-1, 3-thiazole compound, the method and the evaluation have excellent application prospects in the industries of medicines, pesticides and the like.

Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase

Bacterial DNA gyrase is an attractive target for the investigation of new antibacterial agents. Inhibitors of the GyrB subunit, which contains the ATP-binding site, are described in this communication. Novel, substituted 5-(1H-pyrazol-3-yl)thiazole compounds were identified as inhibitors of bacterial gyrase. Structure-guided optimization led to greater enzymatic potency and moderate antibacterial potency. Data are presented for the demonstration of selective enzyme inhibition of Escherichia coli GyrB over Staphlococcus aureus GyrB.