56421-67-1Relevant articles and documents
Synthesis of Decahydrocyclobuta[cd]indene Skeletons: Rhodium(III)-Catalyzed Hydroarylation and Relay Thiophene-Promoted Intramolecular [2+2] Cycloaddition
Gao, Dingding,Wang, Feng,Liu, Xing-Yu,Feng, Kai-Rui,Zhao, Jia-Ying,Wang, Yu-Hui,Yang, Xiao-Di,Tian, Ping,Lin, Guo-Qiang
supporting information, p. 4384 - 4390 (2020/09/23)
The preparation of decahydrocyclobuta[cd]indene skeleton was accomplished through rhodium(III)-catalyzed hydroarylation and relay thiophene-promoted intramolecular [2+2] cycloaddition. This tandem reaction exhibited broad substrate scope (24 examples) and good functional group compatibility. Control experiments revealed the important role of sulfur (S) heteroatom, thus a tentative mechanism with thiophene-promoted double Michael additions was proposed to explain this formal [2+2] cycloaddition. Moreover, the resulting polycyclic products displayed potent anti-cancer activities against breast cancer cell lines MDA-MB-468. (Figure presented.).