56421-70-6Relevant articles and documents
Synthesis of Decahydrocyclobuta[cd]indene Skeletons: Rhodium(III)-Catalyzed Hydroarylation and Relay Thiophene-Promoted Intramolecular [2+2] Cycloaddition
Gao, Dingding,Wang, Feng,Liu, Xing-Yu,Feng, Kai-Rui,Zhao, Jia-Ying,Wang, Yu-Hui,Yang, Xiao-Di,Tian, Ping,Lin, Guo-Qiang
supporting information, p. 4384 - 4390 (2020/09/23)
The preparation of decahydrocyclobuta[cd]indene skeleton was accomplished through rhodium(III)-catalyzed hydroarylation and relay thiophene-promoted intramolecular [2+2] cycloaddition. This tandem reaction exhibited broad substrate scope (24 examples) and good functional group compatibility. Control experiments revealed the important role of sulfur (S) heteroatom, thus a tentative mechanism with thiophene-promoted double Michael additions was proposed to explain this formal [2+2] cycloaddition. Moreover, the resulting polycyclic products displayed potent anti-cancer activities against breast cancer cell lines MDA-MB-468. (Figure presented.).
Synthesis and SAR of 2-phenyl-1-sulfonylaminocyclopropane carboxylates as ADAMTS-5 (Aggrecanase-2) inhibitors
Shiozaki, Makoto,Imai, Hiroto,Maeda, Katsuya,Miura, Tomoya,Yasue, Katsutaka,Suma, Akira,Yokota, Masahiro,Ogoshi, Yosuke,Haas, Julia,Fryer, Andrew M.,Laird, Ellen R.,Littmann, Nicole M.,Andrews, Steven W.,Josey, John A.,Mimura, Takayuki,Shinozaki, Yuichi,Yoshiuchi, Hiromi,Inaba, Takashi
scheme or table, p. 6213 - 6217 (2010/06/19)
A series of 1-sulfonylaminocyclopropanecarboxylates was synthesized as ADAMTS-5 (Aggrecanase-2) inhibitors. After an intensive investigation of the central cyclopropane core including its absolute stereochemistry and substituents, we found compound 22 wit
