56424-41-0Relevant academic research and scientific papers
Two new chiral equivalents of H2S: A thio- and a dithiocarboxylic acid
De March, Pedro,Figueredo, Marta,Font, Josep,Gonzalez, Lluisa,Salgado, Antonio
, p. 2603 - 2606 (1996)
The syntheses of the two new chiral mercapto derivatives (R)-2-[N-(1-phenylethyl)-amino]-1-cyclopentenedithiocarboxylic acid, 5, and (1S,4R)-1-(4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane)thiocarbox ylic acid, 9, are described through easy transformations in good yields.
Chiral Lithium Amido Zincates for Enantioselective 1,2-Additions: Auto-assembling Reagents Involving a Fully Recyclable Ligand
Rouen, Mathieu,Chaumont, Pauline,Barozzino-Consiglio, Gabriella,Maddaluno, Jacques,Harrison-Marchand, Anne
supporting information, p. 9238 - 9242 (2018/06/04)
A methodology consisting in carrying out enantioselective nucleophilic 1,2-additions (ee values up to 97 %) from cheap, easily accessible, and never described before, chiral lithium amido zincates is presented. These multicomponent reactants auto-assemble when mixing, in a 1:1 ratio, a homoleptic diorganozinc (R2Zn) with a chiral lithium amide (CLA). The latter, obtained after a single reductive amination, plays the role of the chiral inductor and is fully recoverable thanks to a simple acid–base wash, allowing being recycled and re-use without loss of stereochemical information.
