56425-85-5

Basic information

• Product Name: Benzene, 1-bromo-4-(pentafluoroethoxy)-
• Synonyms: Benzene, 1-bromo-4-(pentafluoroethoxy)-;1-BroMo-4-pentafluoroethyloxy-benzene;4-Bromopentafluoroethoxybenzene;4-Bromophenyl pentafluoroethyl ether;4-Pentafluoroethoxybromobenzene;p-Bromo(pentafluoroethoxy)benzene;p-Bromophenyl pentafluoroethyl ether;1-broMo-4-(perfluoroethoxy)benzene
• CAS NO: 56425-85-5
• Molecular Formula: C₈H₄BrF₅O
• Molecular Weight: 291.012776
• Mol File: 56425-85-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 186℃
• Flash Point: 83℃
• Appearance: /
• Density: 1.677
• Vapor Pressure: 0.951mmHg at 25°C
• Refractive Index: 1.443
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Benzene, 1-bromo-4-(pentafluoroethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-bromo-4-(pentafluoroethoxy)-(56425-85-5)
• EPA Substance Registry System: Benzene, 1-bromo-4-(pentafluoroethoxy)-(56425-85-5)

Safety Data

• Hazardous Substances Data: 56425-85-5(Hazardous Substances Data)

Usage

General Description

Benzene, 1-bromo-4-(pentafluoroethoxy)- is a chemical compound with the molecular formula C8H4BrF5O. It is a clear, colorless liquid that is primarily used as a solvent and as an intermediate in chemical synthesis. It is considered to be highly hazardous to health and can cause irritation to the skin, eyes, and respiratory system, as well as harm to internal organs if inhaled or ingested. It is classified as a potential human carcinogen and mutagen, and exposure should be minimize and strictly controlled to prevent adverse health effects. This chemical is also regulated under various environmental and occupational health and safety regulations to ensure its safe handling, storage, and disposal.

InChI:InChI=1/C8H4BrF5O/c9-5-1-3-6(4-2-5)15-8(13,14)7(10,11)12/h1-4H

Upstream product

• 106-41-2 4-bromo-phenol 
• 124898-13-1 trimethyl(pentafluoroethyl)silane 
• 74501-94-3 trifluoromethanesulfonate de pentafluoroethyle 
• 404-44-4 fluoro-acetic acid-(4-bromo-phenyl ester) 

Downstream Products

• 86652-84-8 4-(perfluoroethoxy)benzohydrazide 
• 1417885-88-1 2-(4-(perfluoroethoxy)phenyl)-1,3,4-oxadiazole 
• 1417885-89-2 methyl 4-(5-(4-(perfluoroethoxy)phenyl)-1,3,4-oxadiazol-2-yl)benzoate 
• 1417885-90-5 4-(5-(4-(perfluoroethoxy)phenyl)-1,3,4-oxadiazol-2-yl)benzoic acid 
• 1417885-91-6 4-(5-(4-(perfluoroethoxy)phenyl)-1,3,4-oxadiazol-2-yl)benzoyl azide 
• 1417885-18-7 N-[[(2-isopropylphenyl)amino]thioxomethyl]N'-((4-(5-(4-(perfluoroethoxy)phenyl)-1,3,4-oxadiazol-2-yl)phenyl))urea 
• 1417885-24-5 (Z)-1-(3-(2-isopropylphenyl)-4-oxothiazolidin-2-ylidene)-3-(4-(5-(4-(perfluoroethoxy)phenyl)-1,3,4-oxadiazol-2-yl)phenyl)urea 
• 1417885-87-0 ethyl 4-(perfluoroethoxy)benzoate 
• 1448165-32-9 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-(4-(2,2,3,3,3-pentafluoropropoxy)phenyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol 
• 1181214-36-7 4-(1-(4-(pentafluoroethoxy)phenyl)-1H-1,2,4-triazol-3-yl)benzoic acid 
• 1181214-80-1 3-(4-nitrophenyl)-1-(4-(pentafluoroethoxy)phenyl)-1H-1,2,4-triazole 
• 1181213-14-8 (2S,3R,4R,5S,6S)-4-ethoxy-3,5-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl (4-(1-(4-(perfluoroethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)carbamate 

Relevant articles and documents

Synthesis of Pentafluoroethyl Ethers by Silver-Mediated Oxidative Pentafluoroethylation of Alcohols and Phenols

A silver triflate (AgOTf)-mediated oxidative pentafluoroethylation of alcohols and phenols with nucleophilic (pentafluoroethyl)trimethylsilane (TMSCF2CF3) using selectfluor as oxidant under mild reaction conditions was developed. This oxidative coupling protocol utilizes broadly available substrates and easily handled reagents to afford various pentafluoroethyl ethers in moderate to excellent yields. Furthermore, this method was extended to the oxidative heptafluoropropylation and ethoxycarbonyldifluoromethylation of alcohols and phenols for preparation of the corresponding fluoroalkyl ethers.

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