56441-63-5

Basic information

• Product Name: Benzoic acid, 4-[(4-methylphenyl)methoxy]-, ethyl ester
• CAS NO: 56441-63-5
• Molecular Formula: C17H18O3
• Molecular Weight: 270.328
• Mol File: 56441-63-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[(4-methylphenyl)methoxy]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[(4-methylphenyl)methoxy]-, ethyl ester(56441-63-5)
• EPA Substance Registry System: Benzoic acid, 4-[(4-methylphenyl)methoxy]-, ethyl ester(56441-63-5)

Safety Data

• Hazardous Substances Data: 56441-63-5(Hazardous Substances Data)

Upstream product

• 120-47-8 Ethyl 4-hydroxybenzoate 
• 104-82-5 4-Methylbenzyl chloride 

Downstream Products

• 1630012-55-3 C₁₆H₁₄N₂O₃ 
• 1630013-23-8 4-butyl-5-(4-(4-methylbenzyloxy)phenyl)-2H-1,2,4-triazole-3(4H)-one 
• 1630012-80-4 C₂₀H₂₅N₃O₃ 
• 147807-64-5 4-(4-Methyl-benzyloxy)-benzoic acid N'-(2-cyano-ethyl)-hydrazide 
• 56442-19-4 4-((4-methylbenzyl)oxy)benzoic acid 
• 147807-57-6 4-(4-Methyl-benzyloxy)-benzoic acid hydrazide 

Relevant articles and documents

Synthesis and anticonvulsant activity evaluation of 4-butyl-5-(4- alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones

A series of 4-butyl-5-(4-alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones (6a-6u) was designed and synthesized. The anticonvulsant effects and neurotoxicity of the compounds were evaluated with maximal electroshock test and rotarod test. Among the synthetic compounds, 4-butyl-5-(4-(2-fluorinebenzyl)phenyl)-2H-1,2,4- triazole-3 (4H)-one (6k) was the most potent with ED50 value of 27.4 mg/kg and protective index (PI = TD50/ED50) value of 12.0. Besides the anti-MES efficacy, the potency of compound 6k against seizures induced by pentylenetetrazole (PTZ), 3-mercaptopropionic acid (3-MP), and bicuculline (BIC) was also established, which suggested that the mechanisms of action including enhancing of GABAergic activity might be involved in its anticonvulsant activity.

Hypolipidemic analogues of ethyl 4 benzyloxybenzoate

A series of compounds related to ethyl 4-benzyloxybenzoate was synthesized and evaluated for potential hypolipidemic activity in rats. Structure-activity relationships are discussed in terms of cholesterol-lowering activity together with effects on body weight gain and liver lipids. A number of the compounds inhibited cholesterol and free fatty acid biosynthesis from [1-14C]acetate in rat liver slices in vitro. Ethyl 4-benzyloxybenzoate, ethyl 4-benzyloxybenzoic acid, ethyl 4-p-bromobenzyloxybenzoate, and ethyl 4-o-methoxybenzyloxyphenyl acetate exhibited the most favorable spectrum of activity.