56457-18-2

Upstream product

• 26673-31-4 6-chloro-3,4-dihydronaphthalen-1(2H)-one 
• 56456-80-5 7-chloro-1-phenyl-4,5-dihydro-1H-benzo[g]indazole-3-carboxylic acid methyl ester 
• 59-88-1 phenylhydrazine hydrochloride 
• 852409-38-2 ethyl α-(6-chloro-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-α-oxoacetate 
• 852409-46-2 ethyl 7-chloro-1-phenyl-4,5-dihydro-1H-benzo[g]indazole-3-carboxylate 

Downstream Products

• 59337-33-6 7-chloro-1-phenyl-4,5-dihydro-1H-benzo[g]indazole-3-carboxylic acid 2-diethylamino-ethyl ester 

Relevant academic research and scientific papers

Tricyclic pyrazoles. Part 2: Synthesis and biological evaluation of novel 4,5-dihydro-1H-benzo[g]indazole-based ligands for cannabinoid receptors

A series of 4,5-dihydro-1H-benzo[g]indazole-3-carboxamides (2a-k) as analogues of the previously reported CB2 ligands 6-chloro- and 6-methyl-1-(2′,4′-dichlorophenyl)-N-piperidin-1-yl-1, 4-dihydroindeno[1,2-c]pyrazole-3-carboxamides (1a,b) was synthesized and their affinity and selectivity towards CB1 and CB2 receptors were evaluated. Several of the new compounds (2a,b,c,d and i) exhibited CB 1 affinity in the nanomolar range with moderate or negligible affinity towards CB2 receptors. Compounds 2a and c increased intestinal propulsion in mouse. Their pro-kinetic effects were reversed by the reference CB agonist CP-55,940. Consequently, in vivo CB1 antagonistic activity was highlighted for these compounds.

Esters and amides of 4,5-dihydrobenz[g]indazole-3-carboxylic acids and related compounds

Aminoalkyl esters and amides of 4,5-dihydrobenz[g]indazole-3-carboxylic acids and related compounds are described herein. They are useful as anti-ulcer agents, anti-arrhythmic agents, anti-bacterial agents, anti-protozoal agents, anthelmintics, anti-fungal agents, anti-algal agents and anti-inflammatory agents. The compounds are prepared from the appropriate carboxylic acid, alkyl ester, or acid chloride.