56472-19-6

Usage

Physical state

Colorless liquid

Odor

Strong, unpleasant, pungent, skunk-like smell

Usage

a. Production of flavors and fragrances
b. Scent additive to natural gas for leak detection
c. Source of sulfur in organic synthesis
d. Chemical intermediate in the manufacture of pharmaceuticals and agrochemicals

Potential applications

a. Treatment of inflammatory diseases
b. Antimicrobial agent

Upstream product

• 176-72-7 4,4-pentamethylene-1,2-dithiolane 
• 109-06-8 α-picoline 
• 108-89-4 picoline 
• 180688-93-1 4-(2-ethyl-2-mercaptomethylbutylthiomethyl)pyridine 
• 1139-13-5 diethyl cyclohexane-1,1-dicarboxylate 
• 62161-66-4 1,1-bis-methanesulfonyloxymethyl-cyclohexane 
• 2658-60-8 1,1-bis(hydroxymethyl)cyclohexane 
• 41174-10-1 4,4-diethyl-1,2-dithiolane 

Downstream Products

• 176-72-7 4,4-pentamethylene-1,2-dithiolane 

Relevant academic research and scientific papers

Reaction of polymerization-resistant 1,2-dithiolanes with lithiated picolines: Simple ring opening and 1,3-dithiane formation

Reaction of polymerization resistant 1,2-dithiolanes 1 with excess pyridylmethyllithiums 3 in THF gave the corresponding ring-opened products 2 in good yields, but the by-products 2-pyridyl-1,3-dithianes 5 and 1,3-propanedithiols 6 could not be excluded. Addition of hexamethylphosphoric triamide (HMPT) to the reaction mixture resulted in the selective formation of 5.

The Reductive Acylation of Organic Disulfides with Aldehydes under Photochemical and Radical Conditions

The irradiation of organic disulfides in aldehyde solvents resulted in the reductive fission of the S-S linkage, giving an equimolar mixture of the corresponding thiol and thiol acylate in a good yield.The cyclic disulfides gave mono S-acylated dithiols.The reaction proceeded by means of the photo-initiated radical chain mechanism, and AIBN (azobisisobutyronitrile) effected the same reaction under thermal conditions.