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Synthesis of carbamates from amines and dialkyl carbonates: Influence of leaving and entering groups
Tundo, Pietro,McElroy, C. Robert,Aricò, Fabio
experimental part, p. 1567 - 1571 (2010/09/05)
A number of carbamates were synthesised through a halogen-free process by reacting amines with symmetrical and unsymmetrical carbonates. The results obtained showed a specific trend of preferred leaving groups (in the dialkyl carbonates) depending on whether a catalyst or a base was used. On the other hand, investigations conducted on the preferred entering groups (amines) for the synthesis of carbamates showed the same trend regardless of whether a catalyst or a base was used. Finally, in accordance with the results obtained, it was possible to synthesise sterically hindered carbamates in high yield by transesterification of methyl carbamate with a sterically hindered alcohol. Georg Thieme Verlag Stuttgart New York.
