56476-92-7

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 2-phenyl-2H-tetrazole-5-carboxylate is used as a pharmaceutical agent for its antimicrobial, antitumor, and antiviral properties. Its diverse biological activities make it a promising candidate for the development of new drugs to combat various diseases and infections.
Used in Materials Science:
In the field of materials science, methyl 2-phenyl-2H-tetrazole-5-carboxylate is used for its potential applications in the development of new materials. Its unique chemical structure and properties can contribute to the creation of innovative materials with specific characteristics for various industries.

Upstream product

• 186581-53-3 diazomethane 
• 54798-92-4 2-phenyl-2H-tetrazole-5-carboxylic acid 

Downstream Products

• 60092-90-2 C₉H₈N₂O₂ 
• 55408-42-9 2-Phenyl-5-hydroxymethyl-2H-tetrazol 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of antitubercular 2-nitroimidazooxazines bearing heterocyclic side chains

Recently described biphenyl analogues of the antituberculosis drug PA-824 displayed improved potencies against M. tuberculosis but were poorly soluble. Heterobiaryl analogues of these, in which the first phenyl ring was replaced with various 5-membered ring heterocycles, were prepared with the aim of identifying potent new candidates with improved aqueous solubility. The compounds were constructed by coupling the chiral 2-nitroimidazooxazine alcohol with various halomethyl-substituted arylheterocycles, by cycloadditions to a propargyl ether derivative of this alcohol, or by Suzuki couplings on haloheterocyclic methyl ether derivatives. The arylheterocyclic compounds were all more hydrophilic than their corresponding biphenyl analogues, and several showed solubility improvements. 1-Methylpyrazole, 1,3-linked-pyrazole, 2,4-linked-triazole, and tetrazole analogues had 3- to 7-fold higher MIC potencies against replicating M. tb than predicted by their lipophilicities. Two pyrazole analogues were >10-fold more efficacious than the parent drug in a mouse model of acute M. tb infection, and one displayed a 2-fold higher solubility. 2009 American Chemical Society.