56487-68-4

Basic information

• Product Name: (7R)-7-Amino-3-methylcepham-2-ene-4-carboxylic acid
• Synonyms: (7R)-7-Amino-3-methylcepham-2-ene-4-carboxylic acid;Δ-2-7-Aminodesacetoxycephalosporanic Acid;7-ammonio-3-methyl-8-oxo-5-thia-1-azabicyclo[420]oct-3-ene-2-carboxylate
• CAS NO: 56487-68-4
• Molecular Formula: C8H10N2O3S
• Molecular Weight: 214.24
• Mol File: 56487-68-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 513.4±50.0 °C(Predicted)
• Appearance: /
• Density: 1.58±0.1 g/cm3(Predicted)
• PKA: 2.25±0.40(Predicted)
• CAS DataBase Reference: (7R)-7-Amino-3-methylcepham-2-ene-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (7R)-7-Amino-3-methylcepham-2-ene-4-carboxylic acid(56487-68-4)
• EPA Substance Registry System: (7R)-7-Amino-3-methylcepham-2-ene-4-carboxylic acid(56487-68-4)

Safety Data

• Hazardous Substances Data: 56487-68-4(Hazardous Substances Data)

Usage

Uses

Δ-2-7-Aminodesacetoxycephalosporanic Acid is a metabolite of Cephalexin (C256800).

Upstream product

• 851-77-4 3-Methyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 

Relevant articles and documents

Method for preparing 7-ADCA (7-aminodesacetoxycephalosporanic acid)

The invention provides a method for preparing 7-ADCA (7-aminodesacetoxycephalosporanic acid). The method comprises the following steps: (a) adding acylase to an aqueous solution of 7-ADCA for pyrolysis, and removing the acylase after pyrolysis to obtain a lysate; (b) decolorizing the lysate to obtain a to-be-crystallized solution; (c) adding peroxide to the to-be-crystallized solution, adding alcohol to the solution, performing crystallization by acid-base neutralization, adjusting pH to an isoelectric point, and performing solid-liquid separation to obtain 7-ADCA. Peroxide is added to the to-be-crystallized solution obtained after pyrolysis of 7-ADCA by the acylase and decoloration for pretreatment, the to-be-crystallized solution is crystallized in a water-alcohol mixed phase system, thecontent of the obtained product 7-ADCA is higher than 99.5%, the purity is higher than 99.5%, and the 7-ADCA content of the contained relevant substance delta2 is lower than 0.05%. The method is simple and easy to implement, the existing production process of 7-ADCA is simplified, quality of the 7-ADCA product is improved, and the method has broad industrial application prospect.