565-53-7

Basic information

• Product Name: Ethyl dibromofluoroacetate
• Synonyms: DIBROMOFLUOROACETIC ACID ETHYL ESTER;ETHYL DIBROMOFLUOROACETATE;Ethyldibromofluoroacetate,97%;Ethyl dibromofluoroacetate 97%;Fluorodibromoacetic acid ethyl ester;2,2-Dibromo-1-ethoxy-2-fluoroethan-1-one;ethyl 2,2-dibroMo-2-fluoroacetate;Dibromofluoroacetic acid ethyl ester, Ethyl 2,2-dibromo-2-fluoroethanoate
• CAS NO: 565-53-7
• Molecular Formula: C₄H₅Br₂FO₂
• Molecular Weight: 263.89
• EINECS: -0
• Product Categories: Pharmaceutical Intermediates;Fluorinated Building Blocks;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;Synthetic Organic Chemistry
• Mol File: 565-53-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 157-161°C
• Boiling Point: 82 °C
• Flash Point: 82°C/33mm
• Appearance: /
• Density: 1.894
• Refractive Index: 1.4633
• Water Solubility: Miscible with most organic solvents. Immiscible with water.
• BRN: 1762048
• CAS DataBase Reference: Ethyl dibromofluoroacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl dibromofluoroacetate(565-53-7)
• EPA Substance Registry System: Ethyl dibromofluoroacetate(565-53-7)

Safety Data

• Hazard Codes: T,C
• Statements: 21/22-34
• Safety Statements: 26-36/37/39-45-23
• RIDADR: 1760
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 565-53-7(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow liquid

Uses

Ethyl dibromofluoroacetate is a reagent used in the preparation of fluorinated molecules in organic synthesis. It is involved in the Reformatsky-type reaction to prepare syn-alfa-bromo-alfa-fluoro-beta-lactams by using diethylzinc. It is also used to prepare 2-fluoroaziridine-2-carboxylates by reaction with imines.

Upstream product

• 64-17-5 ethanol 
• 430-85-3 1,1-dibromo-2,2-difluoroethylene 
• 599-99-5 ethyl tribromoacetate 

Downstream Products

• 353-99-1 dibromofluoroacetic acid 
• 1977-47-5 α-Fluor-α-cinnamylidenessigsaeure-ethylester 
• 55305-84-5 (Z)-2-Fluoro-3-phenyl-but-2-enoic acid ethyl ester 
• 918667-14-8 ethyl (Z)-5-([tert-butyl(diphenyl)silyl]oxy)-2-fluoro-2-pentenoate 
• 954387-67-8 C₃₈H₃₉FO₇ 
• 1208228-70-9 2-ethoxycarbonyl-2-fluoro-3,3-diphenyloxirane 

Relevant articles and documents

Production process of ethyl bromodifluoroacetate

The invention discloses a production process of ethyl bromodifluoroacetate. The production process comprises the following steps: 1, bromination reaction; 2, elimination reaction; 3, oxidation reaction; 4, esterification reaction. Compared with other methods, the bromination addition reaction only needs to be carried out at normal pressure and under the catalysis of infrared light, so that the cost is saved compared with other catalysts, other impurities are not introduced, and the utilization rate of bromine is increased. The elimination reaction adopts a dropwise adding mode, so the reactionrate can be effectively controlled, and the flooding phenomenon which is easy to generate is avoided. The purity of the prepared finished product is greater than or equal to 99.0%, and the yield is greater than or equal to 80.0%.