56504-53-1

Upstream product

• 67-52-7 BARBITURIC ACID 
• 3132-99-8 m-bromobenzoic aldehyde 

Downstream Products

• 118373-58-3 4-Amino-1-(3-bromo-phenyl)-6,8,10-trioxo-7,9-diaza-spiro[4.5]dec-3-ene-2,2,3-tricarbonitrile 
• 104823-30-5 5-(m-bromo)benzylbarbituric acid 

Relevant academic research and scientific papers

Sulfamic Acid Catalyzed Atom Economic, Eco-friendly Synthesis of Novel 7-(Aryl)-10-thioxo-7,9,10,11-tetrahedro-6H-pyrimido-[5′4′:5,6]pyrano[3,2-c]quinoline-6,8(5H)-dione and its Derivatives

A series of novel 7-(3-chloro-phenyl)-10-thioxo-7,9,10,11-tetrahedro-6H-pyrimido-[5′4′:5,6] pyrano[3,2-c]quinoline-6,8(5H)-dione derivatives have been synthesized through the multi-component condensation of aromatic aldehydes, barbituric acid, and 2,4-dih

SHIKIMATE PATHWAY INHIBITORS AND THE USE THEREOF

The present invention relates to methods of inhibiting shikimate pathway, comprising administering to a subject a pharmaceutically acceptable composition comprising a compound having a formula: or pharmaceutically acceptable salts thereof. The present invention also provides a synergistic antibacterial composition containing compound

Nuclear magnetic resonance and molecular modeling study of exocyclic carbon-carbon double bond polarization in benzylidene barbiturates

Benzylidene barbiturates are important materials for the synthesis of heterocyclic compounds with potential for the development of new drugs. The reactivity of benzylidene barbiturates is mainly controlled by their exocyclic carbon-carbon double bond. In this work, the exocyclic double bond polarization was estimated experimentally by NMR and correlated with the Hammett σ values of the aromatic ring substituents and the molecular modeling calculated atomic charge difference. It is demonstrated that carbon chemical shift differences and NBO charge differences can be used to predict their reactivity.

Antimicrobial efficacy of metal-barbiturate conjugates against pathogenic strains of escherichia coli and staphylococcus aureus

Resistance to commercially available antimicrobials is increasing at alarming rate therefore there is an urgent need of new antimicrobial compounds and materials with novel modes of action to tackle the problem of resistance in pathogenic gram positive and gram negative bacteria. The current study involves the design and synthesis of new molecular structures which should not resemble the basic molecular structures of the existing classes of antimicrobial agents in order to avoid the risks of cross resistance development. A total of 14 metal-barbiturate complexes (newly synthesized compounds) were evaluated for their antimicrobial properties against multiple drug resistance clinical isolates of S. aureus and E. coli. Broth dilution method was used to determine minimum inhibitory and bactericidal activity of the newly synthesized compounds. The results showed that the metal-barbiturate complexes with cobalt ions were more effective against E. coli and S. aureus as compared to other compounds. Moreover the activity of these compounds was higher against S. aureus as compared to E. coli which indicates species specific variable antimicrobial effects of these compounds.

Reaction of hexahydropyirimidine-2,4,6-trione with naphthalen-2-amine and benzaldehydes

Previously unknown 12-aryl-7,8,9,10,11,12-hexahydrobenzo[f]pyrimido[4,5-b] quinoline-9,11-diones were synthesized by three-component condensation of naphthalen-2-amine with substituted benzaldehydes and barbituric acid through intermediate 5-benzylidenebarbituric acids. Nauka/Interperiodica 2007.

Synthesis of a New Class of Uridine Phoshorylase Inhibitors

A new series of potent uridine phosphorylase inhibitors have been prepared from barbituric acid.Among them 1--5-(m-benzyloxy)benzylbarbituric acid (37, BBBA) is the most promising having a Ki value of 1.1 +/- 0.2 nM wit