5651-91-2Relevant academic research and scientific papers
Bis-BODIPY linked-triazole based on catechol core for selective dual detection of Ag+and Hg2+
Saiyasombat, Worakrit,Kiatisevi, Supavadee
, p. 3703 - 3712 (2021)
Herein, we introduced a new chemosensor, bis-BODIPY linked-triazole based on catechol (BODIPY-OO) prepared by bridging two units of BODIPY fluorophore/triazole binding group with a catechol unit. A solution of this compound displayed 4- and 2-fold enhance
Hydrogen-bonding induced construction of a multiple double-helical system via a macrocycle-containing propargylamine backbone
Sun, Yu,An-Xin, Wu
, p. 420 - 424 (2015)
Two macrocyclic compounds containing propargylamine backbone have been synthesised via Mannich three-component reaction. The macrocycle 3a shows the intramolecular self-folding conformation. The macrocycle 3b self-assembles via multiple weak interactions
Synthesis and characterization of novel phenoxy-substituted enediyne-triazole conjugates using click chemistry
Joshi, Mukesh C.
, p. 195 - 202 (2021/03/19)
Novel group of phenoxy-substituted enediyne-triazole conjugates were synthesized by Huisgen [3+2] cycloaddition reaction (Click chemistry) in aqueous media. It was observed that ene-diynes were stable in aqueous medium and open-air conditions.
A copper-catalyzed synthesis of aryloxy-tethered symmetrical 1,2,3-triazoles as potential antifungal agents targeting 14 α-demethylase
Deshmukh, Tejshri R.,Jadhav, Rohit G.,Khedkar, Vijay M.,Sangshetti, Jaiprakash N.,Sarkate, Aniket P.,Shingate, Bapurao B.,Tiwari, Shailee V.
supporting information, p. 13104 - 13118 (2021/08/03)
The search for potent therapeutic agents has prompted the design and synthesis of a library of twenty-six aryloxy-tethered and amide-linked symmetrical 1,2,3-triazoles (8a-z) using a copper(i)-catalyzed click chemistry approach. All the synthesized compounds have been screened for theirin vitroantifungal activity against four different fungal strains as well as the enzymatic study for the inhibition of 14 α-demethylase enzyme. The bioactivity results show that most of the synthesized compounds were found to be better antifungal agents as compared to Miconazole. Among them, compound8ashowed the most promising antifungal activity against all the tested fungal strains. Furthermore, the enzymatic study reveals that compounds8iand8oare the most promising inhibitors of the 14 α-demethylase enzyme. In support of these results, the molecular docking study of the synthesized molecules against the sterol 14 α-demethylase (CYP51) could provide the structural basis for the antifungal activity. These compounds have also been analyzed for the ADME properties.
Novel ferrocene-based 1,2,3-triazolyl compounds: Synthesis, anti-migration properties and catalytic effects on oxidizers during combustion
Cheng, Wenqian,Shi, Xiaoling,Zhang, Yu,Jian, Yajun,Zhang, Guofang
, (2019/12/26)
To tackle high-migratory and high-volatility problem of marketed neutral ferrocene-based burning rate catalysts, twenty-one ferrocene-based 1,2,3-triazolyl compounds (Fc-TAZs) were synthesized by click reaction and characterized completely by NMR, FT-IR,
Triazole-amide isosteric pyridine-based supramolecular gelators in metal ion and biothiol sensing with excellent performance in adsorption of heavy metal ions and picric acid from water
Panja, Atanu,Ghosh, Kumaresh
, p. 934 - 945 (2019/01/09)
Pyridine-based small molecular gelators 1-4, having a triazole-amide isosteric relationship, have been synthesized. Compounds 1-3 exhibit excellent gelation from DMSO-H2O (1?:?2, v/v), while compound 4 forms a gel in the presence of Ag+ ions in DMSO-H2O (1?:?2, v/v). The change from triazole to isosteric amide has a marked effect on the gelling abilities, minimum gelation concentrations (mgc), thermal stability, mechanical properties, metal ion-responsive character and adsorption properties of the structures, as established by various techniques. All the gels have been successfully applied in sophisticated sensing kits for the selective detection of Cu2+ and Ag+ ions and thiol-containing amino acids. The triazole-based gelators 1 and 3 adsorb heavy metal ions from water with greater efficiency than the isosteric amide-based gelators. The metallogel 4-Ag+ can be used in the efficient removal of picric acid (a nitro explosive) from water.
Design and Synthesis of New Aryloxy-linked Dimeric 1,2,3-Triazoles via Click Chemistry Approach: Biological Evaluation and Molecular Docking Study
Deshmukh, Tejshri R.,Khare, Smita P.,Krishna, Vagolu S.,Sriram, Dharmarajan,Sangshetti, Jaiprakash N.,Bhusnure, Omprakash,Khedkar, Vijay M.,Shingate, Bapurao B.
, p. 2144 - 2162 (2019/07/12)
A quest for more potent new antitubercular agents has prompted to design and synthesize aryloxy-linked dimeric 1,2,3-triazoles (4a–j), from azides (2a-e) and bis(prop-2-yn-1-yloxy)benzene (3a–b) on 1,3-dipolar cycloaddition reaction via copper (I)-catalyzed click chemistry approach with good to better yields. The titled compounds (4a–j) were designed using molecular hybridization approach by assembling various bioactive pharmacophoric fragments in a single molecular framework. All the synthesized compounds have been screened for their in vitro antitubercular, antifungal, and antioxidant activities against their respective strains. Among them, 4h and 4i show the highest antifungal activity, whereas compounds 4h, 4i, and 4j have revealed promising antitubercular activity against their respective strains. In addition to this, most of the synthesized compounds were found as potent antifungal and antioxidant agents. A significant network of bonded and non-bonded interactions stabilized these molecules into the active site of fungal CYP51 that is realized from the obtained well-placed docking poses and the associated thermodynamic interactions with the enzyme. The synthesized compounds have also been analyzed for absorption, distribution, metabolism, and excretion properties.
New amide linked dimeric 1,2,3-triazoles bearing aryloxy scaffolds as a potent antiproliferative agents and EGFR tyrosine kinase phosphorylation inhibitors
Deshmukh, Tejshri R.,Sarkate, Aniket P.,Lokwani, Deepak K.,Tiwari, Shailee V.,Azad, Rajaram,Shingate, Bapurao B.
supporting information, (2019/08/20)
A search for potent antiproliferative agents has prompted to design and synthesize aryloxy bridged and amide linked dimeric 1,2,3-triazoles (7a–j) by using 1,3-dipolar cycloaddition reaction between 2-azido-N-phenylacetamides (4a–e) and bis(prop-2-yn-1-yl
Low molecular weight supramolecular dehydroepiandrosterone-based gelators: Synthesis and molecular modeling study
Zhikol, Oleg A.,Shishkina, Svitlana V.,Lipson, Victoria V.,Semenenko, Alexander N.,Mazepa, Alexander V.,Borisov, Alexander V.,Mateychenko, Pavel V.
, p. 13112 - 13121 (2019/08/28)
Three novel isomeric supramolecular dehydroepiandrosterone appended 1,2,3-triazole-based potential gelators were synthesized. Their ability to form gels in different solvents was studied experimentally as well as at the molecular level by means of molecul
Synthesis of novel 1,2,3-triazole based artemisinin derivatives and their antiproliferative activity
Kapkoti, Deepak Singh,Singh, Shilpi,Luqman, Suaib,Bhakuni, Rajendra Singh
, p. 5978 - 5995 (2018/04/23)
Two series of novel 1,2,3-triazole based artemisinin derivatives were designed, synthesized via a copper(i)-catalyzed azide alkyne cycloaddition (CuAAC) reaction and investigated for their antiproliferative activity by MTT assay against various human canc
