565203-83-0Relevant academic research and scientific papers
Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1- yl-benzonitrile as novel farnesyltransferase inhibitor
Lin, Nan-Horng,Wang, Le,Cohen, Jerry,Gu, Wen-Zhen,Frost, David,Zhang, Haiying,Rosenberg, Saul,Sham, Hing
, p. 1293 - 1296 (2003)
Farnesyltransferase inhibitors (FTIs) have emerged as a novel class of anti-cancer agents. Analogues of the potent FTI, 4-[3-biphenyl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl- benzonitrile, were synthesized and tested in vitro for their inhibitory activities. The synthesis and detailed biological data of this series of analogues are presented.
